Newton, Phillip J and Davidson, Patricia M and Krum, Henry and Ollerton, Richard and Macdonald, Peter S (2012) The acute haemodynamic effect of nebulised frusemide in stable, advanced heart failure. Heart Lung and Circulation, 21 (5). pp.260-6. ISSN 1444-2892 (N/A)
Full text not available from this repository.Abstract
PURPOSE
To assess the acute haemodynamic effects of nebulised frusemide in a stable advanced heart failure population.
PROCEDURE
In this randomised, double blind, placebo controlled trial, people with stable, advanced heart failure undergoing right heart catheterisation were randomised to receive either 40 mg (4 ml) of nebulised frusemide or 4 ml of normal saline. Following inhalation of the study medication, subjects' pulmonary pressures were recorded every 15 min for 1 h.
FINDINGS
There were no significant changes in the weighted average time course data of the subjects (n=32) in either group over the study period, in particular no differences were observed in haemodynamic parameters between the two groups. Weighted average pulmonary capillary wedge pressure after 60 min in the frusemide group was 22.5 (SD 6.5) mmHg (n=14) compared to the placebo group's 24.0 (SD 7.3) mmHg (n=18), p=0.55. The frusemide group had a significantly greater change in the median volume of urine in the bladder over the study period (186 ml IQR 137.8-260.8) compared to the placebo group (76 ml IQR 39.0-148.0) p=0.02.
CONCLUSION
This study showed that nebulised frusemide had no significant clinical effect on the haemodynamic characteristics of the subjects.
(No funders listed)
| Item Type: | Article |
|---|---|
| Subjects: | R Medicine > R Medicine (General) |
| Depositing User: | Repository Administrator |
| Date Deposited: | 05 Jan 2016 02:24 |
| Last Modified: | 25 Jan 2018 03:45 |
| URI: | https://eprints.victorchang.edu.au/id/eprint/99 |
Actions (login required)
 |
View Item |