Coleman, J.L.J. and Ngo, T. and Smith, N.J. (2020) Corrigendum to “The G protein-coupled receptor N-terminus and receptor signalling: N-tering a new era” [Cellular Signalling 2017 May;33:1–9]. Cellular Signalling. p. 109510. ISSN 08986568
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Abstract
G protein-coupled receptors (GPCRs) are a vastfamily of membrane-traversing proteins, essential to the ability ofeukaryotic life to detect, and mount an intracellular response to, a diverse range of extracellular stimuli. GPCRshave evolved with archetypal features including an extracellular N-terminus and intracellular C-terminus thatflank a transmembrane structure of seven sequential helices joined by intracellular and extracellular loops.These structural domains contribute to the ability of a GPCR to be correctly synthesised and inserted into thecell membrane, to interact with its cognate ligand(s) and to couple with signal-transducing heterotrimeric G pro-teins, allowing the activated receptor to selectively modulate a number of signalling cascades. Whilst well knownfor its importance in receptor translation and trafficking, the GPCR N-terminus is underexplored as a participantin receptor signalling. This review aims to discuss and integrate recent advances in knowledge of the vital roles ofthe GPCR N-terminus in receptor signalling
| Item Type: | Article |
|---|---|
| Subjects: | R Medicine > R Medicine (General) |
| Depositing User: | Repository Administrator |
| Date Deposited: | 23 Jan 2020 04:46 |
| Last Modified: | 11 Oct 2021 03:36 |
| URI: | https://eprints.victorchang.edu.au/id/eprint/922 |
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