Jaïs, Xavier and Olsson, Karen M and Barbera, Joan A and Blanco, Isabel and Torbicki, Adam and Peacock, Andrew and Vizza, C Dario and Macdonald, Peter S and Humbert, Marc and Hoeper, Marius M (2012) Pregnancy outcomes in pulmonary arterial hypertension in the modern management era. The European Respiratory Journal, 40 (4). pp.881-5. ISSN 1399-3003 (OA)
Full text not available from this repository.Abstract
Previous studies have reported mortality rates of up to 56% associated with pregnancy in pulmonary arterial hypertension (PAH) but the management of this disease has changed considerably in recent years. We compiled a multinational, prospective registry to examine the contemporary outcome of pregnancies in patients with PAH. During a 3-yr period, the 13 participating centres reported 26 pregnancies. Three (12%) females died and one (4%) developed right heart failure requiring urgent heart-lung transplantation. There were eight abortions; two spontaneous and six induced. 16 (62%) pregnancies were successful, i.e. the females delivered healthy babies without complications. These females had well controlled PAH (pulmonary vascular resistance (PVR) 500 ± 352 dyn·s·cm(-5)); eight of them were long-term responders to calcium channel blockers. In contrast, the females who died or required transplantation had poorly controlled PAH (PVR 1,667 ± 209 dyn·s·cm(-5)). Pregnancy remains associated with a substantial mortality rate in PAH. However, our results indicate that the outcome of pregnancy in PAH has improved, at least when PAH is well controlled, and particularly in long-term responders to calcium channel blockers. These data must be confirmed by larger series before the general recommendation to avoid pregnancy in all patients with PAH is reconsidered.
(Funders not listed)
| Item Type: | Article |
|---|---|
| Subjects: | R Medicine > R Medicine (General) |
| Depositing User: | Repository Administrator |
| Date Deposited: | 04 Jan 2016 04:07 |
| Last Modified: | 22 Mar 2016 02:25 |
| URI: | https://eprints.victorchang.edu.au/id/eprint/81 |
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