Wang, Louis W and Kesteven, Scott H and Huttner, Inken G and Feneley, Michael P and Fatkin, Diane (2018) High-Frequency Echocardiography ― Transformative Clinical and Research Applications in Humans, Mice, and Zebrafish. Circulation Journal, ePub. ISSN 1346-9843 (OA)
Full text not available from this repository.Abstract
Echocardiography is an invaluable tool for characterizing cardiac structure and function in vivo. Technological advances in high-frequency ultrasound over the past 3 decades have increased spatial and temporal resolution, and facilitated many important clinical and basic science discoveries. Successful reverse translation of established echocardiographic techniques, including M-mode, B-mode, color Doppler, pulsed-wave Doppler, tissue Doppler and, most recently, myocardial deformation imaging, from clinical cardiology into the basic science laboratory has enabled researchers to achieve a deeper understanding of myocardial phenotypes in health and disease. With high-frequency echocardiography, detailed evaluation of ventricular systolic function in a range of small animal models is now possible. Furthermore, improvements in frame rate and the advent of diastolic strain rate imaging, when coupled with the use of select pulsed-wave Doppler parameters, such as isovolumic relaxation time and E wave deceleration, have enabled nuanced interpretation of ventricular diastolic function. Comparing pulsed-wave Doppler indices of atrioventricular inflow during early and late diastole with parameters that describe the simultaneous myocardial deformation (e.g., tissue Doppler é and á, global longitudinal strain rate and global longitudinal velocity) may yield additional insights related to myocardial compliance. This review will provide a historical perspective of the development of high-frequency echocardiography and consider how ongoing innovation will help future-proof this important imaging modality for 21st century translational research.
| Item Type: | Article |
|---|---|
| Additional Information: | This article is available for free from the publisher's website. Please click link above |
| Subjects: | R Medicine > R Medicine (General) |
| Depositing User: | Repository Administrator |
| Date Deposited: | 12 Feb 2018 06:05 |
| Last Modified: | 12 Feb 2018 06:06 |
| URI: | https://eprints.victorchang.edu.au/id/eprint/694 |
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