Watson, Alasdair J and Gao, Ling and Sun, Lin and Tsun, Jireh and Doyle, Aoife and Faddy, S C and Jabbour, Andrew and Orr, Yishay and Dhital, Kumud and Hicks, Mark and Jansz, Paul and Macdonald, Peter S (2013) Enhanced preservation of pig cardiac allografts by combining erythropoietin with glyceryl trinitrate and zoniporide. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 13 (7). pp.1676-87. ISSN 1600-6143
Full text not available from this repository.Abstract
Erythropoietin has a tissue-protective effect independent of its erythropoietic effect that may be enhanced by combining it with the nitric oxide donor glyceryl trinitrate (GTN) and the sodium-hydrogen exchange inhibitor zoniporide in rat hearts stored with an extracellular-based preservation solution (EBPS). We thus sought to test this combination of agents in a porcine model of orthotopic heart transplantation incorporating donor brain death and total ischaemic time of approximately 260 min. Pig hearts were stored in one of four storage solutions: unmodified EBPS (CON), EBPS supplemented with GTN and zoniporide (GZ), EBPS supplemented with erythropoietin and zoniporide (EZ), or EBPS supplemented with all three agents (EGZ). A total of 4/5 EGZ hearts were successfully weaned from cardiopulmonary bypass compared with only 2/5 GZ hearts, 0/5 CON hearts and 0/5 EG hearts (p = 0.017). Following weaning from bypass EGZ hearts demonstrated superior contractility and haemodynamics than GZ hearts. All weaned hearts displayed impaired diastolic function. Release of troponin I from EGZ hearts was lower than all other groups. In conclusion, supplementation of EBPS with erythropoietin, glyceryl trinitrate and zoniporide provided superior donor heart preservation than all other strategies tested.
(NHMRC program grant 573732).
| Item Type: | Article |
|---|---|
| Subjects: | R Medicine > R Medicine (General) |
| Depositing User: | Repository Administrator |
| Date Deposited: | 22 Dec 2015 03:12 |
| Last Modified: | 27 Oct 2016 02:46 |
| URI: | https://eprints.victorchang.edu.au/id/eprint/59 |
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