Coleman, James L J and Ngo, Tony and Smith, Nicola J (2017) The G protein-coupled receptor N-terminus and receptor signalling: N-tering a new era. Cellular Signalling, 33. pp.1-9. ISSN 1873-3913 (PP OA)
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Abstract
G protein-coupled receptors (GPCRs) are a vast family of membrane-traversing proteins, essential to the ability of eukaryotic life to detect, and mount an intracellular response to, a diverse range of extracellular stimuli. GPCRs have evolved with archetypal features including an extracellular N-terminus and intracellular C-terminus that flank a transmembrane structure of seven sequential helices joined by intracellular and extracellular loops. These structural domains contribute to the ability of a GPCR to be correctly synthesised and inserted into the cell membrane, to interact with its cognate ligand(s) and to couple with signal-transducing heterotrimeric G proteins, allowing the activated receptor to selectively modulate a number of signalling cascades. Whilst well known for its importance in receptor translation and trafficking, the GPCR N-terminus is underexplored as a participant in receptor signalling. This review aims to discuss and integrate recent advances in knowledge of the vital roles of the GPCR N-terminus in receptor signalling.
| Item Type: | Article |
|---|---|
| Additional Information: | Pre print on file. Embargoed until FEB 2018 |
| Subjects: | R Medicine > R Medicine (General) |
| Depositing User: | Repository Administrator |
| Date Deposited: | 14 Feb 2017 01:13 |
| Last Modified: | 18 Jan 2018 05:19 |
| URI: | https://eprints.victorchang.edu.au/id/eprint/544 |
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