Syeda, Ruhma and Florendo, Maria N and Cox, Charles D and Kefauver, Jennifer M and Santos, Jose S and Martinac, Boris and Patapoutian, Ardem (2016) Piezo1 Channels Are Inherently Mechanosensitive. Cell Reports, 17 (7). pp.1739-1746. ISSN 2211-1247 (OA)
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Abstract
The conversion of mechanical force to chemical signals is critical for many biological processes, including the senses of touch, pain, and hearing. Mechanosensitive ion channels play a key role in sensing the mechanical stimuli experienced by various cell types and are present in organisms from bacteria to mammals. Bacterial mechanosensitive channels are characterized thoroughly, but less is known about their counterparts in vertebrates. Piezos have been recently established as ion channels required for mechanotransduction in disparate cell types in vitro and in vivo. Overexpression of Piezos in heterologous cells gives rise to large mechanically activated currents; however, it is unclear whether Piezos are inherently mechanosensitive or rely on alternate cellular components to sense mechanical stimuli. Here, we show that mechanical perturbations of the lipid bilayer alone are sufficient to activate Piezo channels, illustrating their innate ability as molecular force transducers.
| Item Type: | Article |
|---|---|
| Additional Information: | This article is distributed under the terms of the Creative Commons Attribution 4.0 License (https://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial use, distribution, and reproduction, provided the original author and source are credited. |
| Subjects: | R Medicine > R Medicine (General) |
| Depositing User: | Repository Administrator |
| Date Deposited: | 10 Nov 2016 21:27 |
| Last Modified: | 17 Jan 2018 22:14 |
| URI: | https://eprints.victorchang.edu.au/id/eprint/512 |
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