Xiang, M S W and Kikuchi, Kazu (2016) Endogenous Mechanisms of Cardiac Regeneration. International Review of Cell and Molecular Biology, 326. pp.67-131. ISSN 1937-6448 (Book Chapter _OA not required)
Full text not available from this repository.Abstract
Zebrafish possess a remarkable capacity for cardiac regeneration throughout their lifetime, providing a model for investigating endogenous cellular and molecular mechanisms regulating myocardial regeneration. By contrast, adult mammals have an extremely limited capacity for cardiac regeneration, contributing to mortality and morbidity from cardiac diseases such as myocardial infarction and heart failure. However, the viewpoint of the mammalian heart as a postmitotic organ was recently revised based on findings that the mammalian heart contains multiple undifferentiated cell types with cardiogenic potential as well as a robust regenerative capacity during a short period early in life. Although it occurs at an extremely low level, continuous cardiomyocyte turnover has been detected in adult mouse and human hearts, which could potentially be enhanced to restore lost myocardium in damaged human hearts. This review summarizes and discusses recent advances in the understanding of endogenous mechanisms of cardiac regeneration.
| Item Type: | Article |
|---|---|
| Additional Information: | Published: Elsevier September 2016 (Book Chapter - OA not required by NHMRC) |
| Subjects: | R Medicine > R Medicine (General) |
| Depositing User: | Repository Administrator |
| Date Deposited: | 01 Sep 2016 00:48 |
| Last Modified: | 28 Sep 2016 23:56 |
| URI: | https://eprints.victorchang.edu.au/id/eprint/482 |
Actions (login required)
 |
View Item |