Leong, Chin-Neng and Lim, Einly and Andriyana, Andri and Al Abed, Amr and Lovell, Nigel Hamilton and Hayward, Christopher S and Hamilton-Craig, Christian and Dokos, Socrates (2017) The Role of Infarct Transmural Extent in Infarct Extension: A Computational Study. International Journal for Numerical Methods in Biomedical Engineering, 33 (2). pp. e02794. ISSN 2040-7947 (N/A)
Full text not available from this repository.Abstract
Infarct extension, a process involving progressive extension of the infarct zone (IZ) into the normally perfused border zone (BZ), leads to continuous degradation of the myocardial function and adverse remodeling. Despite carrying a high risk of mortality, detailed understanding of the mechanisms leading to BZ hypoxia and infarct extension remains unexplored. In the present study, we developed a 3D truncated ellipsoidal left ventricular (LV) model incorporating realistic electromechanical properties and fiber orientation to examine the mechanical interaction among the remote, infarct and border zones in the presence of varying infarct transmural extent (TME). Localized highly abnormal systolic fiber stress was observed at the BZ, owing to the simultaneous presence of moderately increased stiffness and fiber strain at this region, caused by the mechanical tethering effect imposed by the overstretched IZ. Our simulations also demonstrated the greatest tethering effect and stress in BZ regions with fiber direction tangential to the BZ-RZ boundary. This can be explained by the lower stiffness in the cross-fiber direction, which gave rise to a greater stretching of the IZ in this direction. The average fiber strain of the IZ, as well as the maximum stress in the subendocardial layer increased steeply from 10% to 50% infarct TME, and slower thereafter. Based on our stress-strain loop analysis, we found impairment in the myocardial energy efficiency and elevated energy expenditure with increasing infarct TME, which we believe to place the BZ at further risk of hypoxia. This article is protected by copyright. All rights reserved.
| Item Type: | Article |
|---|---|
| Additional Information: | ePub 2016 |
| Subjects: | R Medicine > R Medicine (General) |
| Depositing User: | Repository Administrator |
| Date Deposited: | 17 Jun 2016 04:43 |
| Last Modified: | 19 Jan 2018 08:21 |
| URI: | https://eprints.victorchang.edu.au/id/eprint/454 |
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