Ng, Chai Ann and Torres, Allan M and Pagès, Guilhem and Kuchel, Philip W and Vandenberg, Jamie I (2013) Insights into hERG K+ channel structure and function from NMR studies. EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS, 42 (1). pp.71-9. ISSN 1432-1017 (Not OA)
Full text not available from this repository.Abstract
The unique gating kinetics of hERG K(+) channels are critical for normal cardiac repolarization, and patients with mutations in hERG have a markedly increased risk of cardiac arrhythmias and sudden cardiac arrest. HERG K(+) channels are also remarkably promiscuous with respect to drug binding, which has been a very significant problem for the pharmaceutical industry. Here, we review the progress that has been made in understanding the structure and function of hERG K(+) channels with a particular focus on nuclear magnetic resonance studies of the domains of the hERG K(+) channel.
(National Health and Medical Research Council grants 459401, 1019693; National Heart Foundation of Australia
G09S-450, G11S-5829 and the Australian Research Council DP0986316).
| Item Type: | Article |
|---|---|
| Subjects: | R Medicine > R Medicine (General) |
| Depositing User: | Repository Administrator |
| Date Deposited: | 21 Dec 2015 03:48 |
| Last Modified: | 09 Mar 2018 05:08 |
| URI: | https://eprints.victorchang.edu.au/id/eprint/28 |
Actions (login required)
 |
View Item |