Casas, Ana I and Dao, V Thao-Vi and Daiber, Andreas and Maghzal, Ghassan J and Di Lisa, Fabio and Kaludercic, Nina and Leach, Sonia and Cuadrado, Antonio and Jaquet, Vincent and Seredenina, Tamara and Krause, Karl H and López, Manuela G and Stocker, Roland and Ghezzi, Pietro and Schmidt, Harald H H W (2015) Reactive Oxygen-Related Diseases: Therapeutic Targets and Emerging Clinical Indications. Antioxidants & Redox Signaling, 23 (14). pp.1171-85. ISSN 1557-7716 (OA)
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Abstract
SIGNIFICANCE
Enhanced levels of reactive oxygen species (ROS) have been associated with different disease states. Most attempts to validate and exploit these associations by chronic antioxidant therapies have provided disappointing results. Hence, the clinical relevance of ROS is still largely unclear.
RECENT ADVANCES
We are now beginning to understand the reasons for these failures, which reside in the many important physiological roles of ROS in cell signaling. To exploit ROS therapeutically, it would be essential to define and treat the disease-relevant ROS at the right moment and leave physiological ROS formation intact. This breakthrough seems now within reach.
CRITICAL ISSUES
Rather than antioxidants, a new generation of protein targets for classical pharmacological agents includes ROS-forming or toxifying enzymes or proteins that are oxidatively damaged and can be functionally repaired.
FUTURE DIRECTIONS
Linking these target proteins in future to specific disease states and providing in each case proof of principle will be essential for translating the oxidative stress concept into the clinic. Antioxid. Redox Signal. 23, 1171-1185.
| Item Type: | Article |
|---|---|
| Additional Information: | Published by Mary Ann Liebert, Inc. This Open Access article is distributed under the terms of the Creative Commons Attribution Noncommercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited. |
| Subjects: | R Medicine > R Medicine (General) |
| Depositing User: | Repository Administrator |
| Date Deposited: | 02 Feb 2016 23:17 |
| Last Modified: | 28 Apr 2016 01:14 |
| URI: | https://eprints.victorchang.edu.au/id/eprint/279 |
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