Frijhoff, Jeroen and Winyard, Paul G and Zarkovic, Neven and Davies, Sean S and Stocker, Roland and Cheng, David and Knight, Annie R and Taylor, Emma Louise and Oettrich, Jeannette and Ruskovska, Tatjana and Gasparovic, Ana Cipak and Cuadrado, Antonio and Weber, Daniela and Poulsen, Henrik Enghusen and Grune, Tilman and Schmidt, Harald H H W and Ghezzi, Pietro (2015) Clinical Relevance of Biomarkers of Oxidative Stress. Antioxidants & Redox Signaling, 23 (14). pp.1144-70. ISSN 1557-7716 (OA)
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Abstract
SIGNIFICANCE
Oxidative stress is considered to be an important component of various diseases. A vast number of methods have been developed and used in virtually all diseases to measure the extent and nature of oxidative stress, ranging from oxidation of DNA to proteins, lipids, and free amino acids.
RECENT ADVANCES
An increased understanding of the biology behind diseases and redox biology has led to more specific and sensitive tools to measure oxidative stress markers, which are very diverse and sometimes very low in abundance.
CRITICAL ISSUES
The literature is very heterogeneous. It is often difficult to draw general conclusions on the significance of oxidative stress biomarkers, as only in a limited proportion of diseases have a range of different biomarkers been used, and different biomarkers have been used to study different diseases. In addition, biomarkers are often measured using nonspecific methods, while specific methodologies are often too sophisticated or laborious for routine clinical use.
FUTURE DIRECTIONS
Several markers of oxidative stress still represent a viable biomarker opportunity for clinical use. However, positive findings with currently used biomarkers still need to be validated in larger sample sizes and compared with current clinical standards to establish them as clinical diagnostics. It is important to realize that oxidative stress is a nuanced phenomenon that is difficult to characterize, and one biomarker is not necessarily better than others. The vast diversity in oxidative stress between diseases and conditions has to be taken into account when selecting the most appropriate biomarker. Antioxid. Redox Signal. 23, 1144-1170.
| Item Type: | Article |
|---|---|
| Additional Information: | This Open Access article is distributed under the terms of the Creative Commons Attribution Noncommercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited. |
| Subjects: | R Medicine > R Medicine (General) |
| Depositing User: | Repository Administrator |
| Date Deposited: | 02 Feb 2016 06:20 |
| Last Modified: | 28 Apr 2016 01:35 |
| URI: | https://eprints.victorchang.edu.au/id/eprint/276 |
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