Kikuchi, Kazu (2015) Dedifferentiation, Transdifferentiation, and Proliferation: Mechanisms Underlying Cardiac Muscle Regeneration in Zebrafish. Current Pathobiology Reports, 3 (1). pp.81-88. ISSN 2167-485X (OA)
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Abstract
The adult mammalian heart is increasingly recognized as a regenerative organ with a measurable capacity to replenish cardiomyocytes throughout its lifetime, illuminating the possibility of stimulating endogenous regenerative capacity to treat heart diseases. Unlike mammals, certain vertebrates possess robust capacity for regenerating a damaged heart, providing a model to understand how regeneration could be augmented in injured human hearts. Facilitated by its rich history in the study of heart development, the teleost zebrafish Danio rerio has been established as a robust model to investigate the underlying mechanism of cardiac regeneration. This review discusses the current understanding of the endogenous mechanisms behind cardiac regeneration in zebrafish, with a particular focus on cardiomyocyte dedifferentiation, transdifferentiation, and proliferation.
(NHMRC grants 1032522, 1046469)
| Item Type: | Article |
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| Additional Information: | This article is distributed under the terms of the Creative Commons Attribution 4.0 License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
| Subjects: | R Medicine > R Medicine (General) |
| Depositing User: | Repository Administrator |
| Date Deposited: | 28 Jan 2016 04:12 |
| Last Modified: | 28 Sep 2016 05:41 |
| URI: | https://eprints.victorchang.edu.au/id/eprint/265 |
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