Smith, Nicola J (2012) Low affinity GPCRs for metabolic intermediates: challenges for pharmacologists. Frontiers in endocrinology, 3. p. 1. ISSN 1664-2392 (OA)
Full text not available from this repository.Abstract
The discovery that a number of metabolites and metabolic intermediates can act through G protein-coupled receptors has attracted great interest in the field and has led to new therapeutic targets for diseases such as hypertension, type 2 diabetes, inflammation, and metabolic syndrome. However, the low apparent affinity of these ligands for their cognate receptors poses a number of challenges for pharmacologists interested in investigating receptor structure, function or physiology. Furthermore, the endogenous ligands matched to their receptors have other, well established metabolic roles and thus selectivity is difficult to achieve. This review discusses some of the issues researchers face when working with these receptors and highlights the ways in which a number of these obstacles have been overcome.
(NHMRC / National Heart Foundation C.J. Martin Fellowship grant).
| Item Type: | Article |
|---|---|
| Subjects: | R Medicine > R Medicine (General) |
| Depositing User: | Repository Administrator |
| Date Deposited: | 21 Dec 2015 03:33 |
| Last Modified: | 08 Mar 2016 00:30 |
| URI: | https://eprints.victorchang.edu.au/id/eprint/25 |
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