Hilder, Tamsyn A and Ridone, Pietro and Nakayama, Yoshitaka and Martinac, Boris and Chung, Shin-Ho (2014) Binding of fullerenes and nanotubes to MscL. Scientific Reports, 4. p. 5609. ISSN 2045-2322 (OA)
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Abstract
Multi-drug resistance is becoming an increasing problem in the treatment of bacterial infections and diseases. The mechanosensitive channel of large conductance (MscL) is highly conserved among prokaryotes. Evidence suggests that a pharmacological agent that can affect the gating of, or block the current through, MscL has significant potential as a new class of antimicrobial compound capable of targeting a range of pathogenic bacteria with minimal side-effects to infected patients. Using molecular dynamics we examine the binding of fullerenes and nanotubes to MscL and demonstrate that both are stable within the MscL pore. We predict that fullerenes will attenuate the flow of ions through MscL by reducing the pore volume available to water and ions, but nanotubes will prevent pore closure resulting in a permanently open pore. Moreover, we confirm experimentally that it is possible to attenuate the flow of ions through MscL using a C60-γ cyclodextrin complex.
(ARC DECRA, NHMRC grants)
| Item Type: | Article |
|---|---|
| Additional Information: | This work is licensed under a Creative Commons Attribution-NonCommercial- ShareAlike 4.0 International License. http://creativecommons.org/licenses/by-nc-sa/4.0/ |
| Subjects: | R Medicine > R Medicine (General) |
| Depositing User: | Repository Administrator |
| Date Deposited: | 21 Jan 2016 05:42 |
| Last Modified: | 24 May 2016 07:12 |
| URI: | https://eprints.victorchang.edu.au/id/eprint/188 |
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