Cox, Charles D. and Poole, Kate and Martinac, Boris (2024) Re-evaluating TRP channel mechanosensitivity. Trends in Biochemical Sciences, 49 (8). pp.693-702. ISSN 09680004
Full text not available from this repository.Abstract
Transient receptor potential (TRP) channels are implicated in a wide array of mechanotransduction processes. However, a question remains whether TRP channels directly sense mechanical force, thus acting as primary mechanotransducers. We use several recent examples to demonstrate the difficulty in definitively ascribing mechanosensitivity to TRP channel subfamilies. Ultimately, despite being implicated in an ever-growing list of mechanosignalling events in most cases limited robust or reproducible evidence supports the contention that TRP channels act as primary transducers of mechanical forces. They either (i) possess unique and as yet unspecified structural or local requirements for mechanosensitivity; or (ii) act as mechanoamplifiers responding downstream of the activation of a primary mechanotransducer that could include Ca(2+)-permeable mechanosensitive (MS) channels or other potentially unidentified mechanosensors.
| Item Type: | Article |
|---|---|
| Subjects: | R Medicine > R Medicine (General) |
| Depositing User: | Repository Administrator |
| Date Deposited: | 27 Dec 2024 04:04 |
| Last Modified: | 27 Dec 2024 04:04 |
| URI: | https://eprints.victorchang.edu.au/id/eprint/1580 |
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