Biomaterials containing extracellular matrix molecules as biomimetic next-generation vascular grafts

Jiang, Shouyuan and Wise, Steven G. and Kovacic, Jason C. and Rnjak-Kovacina, Jelena and Lord, Megan S. (2024) Biomaterials containing extracellular matrix molecules as biomimetic next-generation vascular grafts. Trends in Biotechnology, 42 (3). pp.369-381. ISSN 01677799

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Link to published document: http://doi.org/10.1016/j.tibtech.2023.09.009

Abstract

The performance of synthetic biomaterial vascular grafts for the bypass of stenotic and dysfunctional blood vessels remains an intractable challenge in small-diameter applications. The functionalization of biomaterials with extracellular matrix (ECM) molecules is a promising approach because these molecules can regulate multiple biological processes in vascular tissues. In this review, we critically examine emerging approaches to ECM-containing vascular graft biomaterials and explore opportunities for future research and development toward clinical use.

Item Type: Article
Subjects: R Medicine > R Medicine (General)
Depositing User: Repository Administrator
Date Deposited: 16 Dec 2024 03:56
Last Modified: 16 Dec 2024 03:56
URI: https://eprints.victorchang.edu.au/id/eprint/1531

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