Friedman, Clayton E. and Cheetham, Seth W. and Negi, Sumedha and Mills, Richard J. and Ogawa, Masahito and Redd, Meredith A. and Chiu, Han Sheng and Shen, Sophie and Sun, Yuliangzi and Mizikovsky, Dalia and Bouveret, Romaric and Chen, Xiaoli and Voges, Holly K. and Paterson, Scott and De Angelis, Jessica E. and Andersen, Stacey B. and Cao, Yuanzhao and Wu, Yang and Jafrani, Yohaann M.A. and Yoon, Sohye and Faulkner, Geoffrey J. and Smith, Kelly A. and Porrello, Enzo and Harvey, Richard P. and Hogan, Benjamin M. and Nguyen, Quan and Zeng, Jian and Kikuchi, Kazu and Hudson, James E. and Palpant, Nathan J. (2024) HOPX-associated molecular programs control cardiomyocyte cell states underpinning cardiac structure and function. Developmental Cell, 59 (1). pp. 91-107.e6. ISSN 15345807
Full text not available from this repository.Abstract
Genomic regulation of cardiomyocyte differentiation is central to heart development and function. This study uses genetic loss-of-function human-induced pluripotent stem cell-derived cardiomyocytes to evaluate the genomic regulatory basis of the non-DNA-binding homeodomain protein HOPX. We show that HOPX interacts with and controls cardiac genes and enhancer networks associated with diverse aspects of heart development. Using perturbation studies in vitro, we define how upstream cell growth and proliferation control HOPX transcription to regulate cardiac gene programs. We then use cell, organoid, and zebrafish regeneration models to demonstrate that HOPX-regulated gene programs control cardiomyocyte function in development and disease. Collectively, this study mechanistically links cell signaling pathways as upstream regulators of HOPX transcription to control gene programs underpinning cardiomyocyte identity and function.
| Item Type: | Article |
|---|---|
| Subjects: | R Medicine > R Medicine (General) |
| Depositing User: | Repository Administrator |
| Date Deposited: | 14 Dec 2024 02:08 |
| Last Modified: | 14 Dec 2024 02:08 |
| URI: | https://eprints.victorchang.edu.au/id/eprint/1509 |
Actions (login required)
 |
View Item |