Macdonald, Peter S. and Gorrie, Natasha and Brennan, Xavier and Aili, Samira R. and De Silva, Ricardo and Jha, Sunita R. and Fritis-Lamora, Rodrigo and Montgomery, Elyn and Wilhelm, Kay and Pierce, Rachel and Lam, Fiona and Schnegg, Bruno and Hayward, Christopher and Jabbour, Andrew and Kotlyar, Eugene and Muthiah, Kavitha and Keogh, Anne M. and Granger, Emily and Connellan, Mark and Watson, Alasdair and Iyer, Arjun and Jansz, Paul C. (2021) The impact of frailty on mortality after heart transplantation. The Journal of Heart and Lung Transplantation, 40 (2). pp.87-94. ISSN 10532498
Full text not available from this repository.Abstract
BACKGROUND: Frailty is prevalent in the patients with advanced heart failure; however, its impact on clinical outcomes after heart transplantation (HTx) is unclear. The aim of this study was to assess the impact of pre-transplant frailty on mortality and the duration of hospitalization after HTx. METHODS: We retrospectively reviewed the post-transplant outcomes of 140 patients with advanced heart failure who had undergone frailty assessment within the 6-month interval before HTx: 43 of them were frail (F) and 97 were non-frail (NF). RESULTS: Post-transplant survival rates for the NF cohort at 1 and 12 months were 97% (93-100) and 95% (91-99) (95% CI), respectively. In contrast, post-transplant survival rates for the F cohort at the same time points were 86% (76-96) and 74% (60-84) (p < 0.0008 vs NF cohort), respectively. The Cox proportional hazards regression analysis demonstrated that pre-transplant frailty was an independent predictor of post-transplant mortality with a hazard ratio of 3.8 (95% CI: 1.4-10.5). Intensive care unit and hospital length of stay were 2 and 7 days longer in the F cohort (both p < 0.05), respectively, than in the NF cohort. CONCLUSIONS: Frailty within 6 months before HTx is independently associated with increased mortality and prolonged hospitalization after transplantation. Future research should focus on the development of strategies to mitigate the adverse effects of pre-transplant frailty.
| Item Type: | Article |
|---|---|
| Subjects: | R Medicine > R Medicine (General) |
| Depositing User: | Repository Administrator |
| Date Deposited: | 15 Mar 2021 04:43 |
| Last Modified: | 15 Mar 2021 04:43 |
| URI: | https://eprints.victorchang.edu.au/id/eprint/1045 |
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