Items where Author is "Vandenberg, Jamie I"

Article

Heitmann, Stewart and Vandenberg, Jamie I and Hill, Adam P (2023) Assessing drug safety by identifying the axis of arrhythmia in cardiomyocyte electrophysiology. eLife, 12. ISSN 2050-084X

Copier, Jaël S and Bootsma, Marianne and Ng, Chai A and Wilde, Arthur A M and Bertels, Robin A and Bikker, Hennie and Christiaans, Imke and van der Crabben, Saskia N and Hol, Janna A and Koopmann, Tamara T and Knijnenburg, Jeroen and Lommerse, Aafke A J and van der Smagt, Jasper J and Bezzina, Connie R and Vandenberg, Jamie I and Verkerk, Arie O and Barge-Schaapveld, Daniela Q C M and Lodder, Elisabeth M (2022) Reclassification of a likely pathogenic Dutch founder variant in KCNH2; implications of reduced penetrance. Human Molecular Genetics, 32 (7). pp.1072-1082. ISSN 0964-6906

Kerr, Nicholas P and Vandenberg, Jamie I (2022) The yin and yang of Tbx5 variant effects on sodium channel function. Cardiovascular Research, 118 (4). pp.929-931. ISSN 0008-6363

Ballouz, Sara and Mangala, Melissa M and Perry, Matthew D and Heitmann, Stewart and Gillis, Jesse A and Hill, Adam P and Vandenberg, Jamie I (2021) Co-expression of calcium and hERG potassium channels reduces the incidence of proarrhythmic events. Cardiovascular Research, 117 (10). pp.2216-2227. ISSN 0008-6363

Ng, Chai-Ann and Farr, Jessica and Young, Paul and Windley, Monique J and Perry, Matthew D and Hill, Adam P and Vandenberg, Jamie I (2021) Heterozygous KCNH2 variant phenotyping using Flp-In HEK293 and high-throughput automated patch clamp electrophysiology. Biology Methods and Protocols, 6 (1). ISSN 2396-8923

Perry, Matthew D and Ng, Chai-Ann and Mangala, Melissa M and Ng, Timothy Y M and Hines, Adam D and Liang, Whitney and Xu, Michelle J O and Hill, Adam P and Vandenberg, Jamie I (2020) Pharmacological activation of IKr in models of long QT Type 2 risks overcorrection of repolarization. Cardiovascular Research, 116 (8). pp.1434-1445. ISSN 0008-6363

Lee, William and Windley, Monique J and Perry, Matthew D and Vandenberg, Jamie I and Hill, Adam (2019) Protocol-dependent differences in IC50 values measured in hERG assays occur in a predictable way and can be used to quantify state preference of drug binding. Molecular Pharmacology, ePub. pp. mol.118.115220. ISSN 0026-895X (OA)

Munawar, Saba and Windley, Monique J and Tse, Edwin G and Todd, Matthew H and Hill, Adam P and Vandenberg, Jamie I and Jabeen, Ishrat (2018) Experimentally Validated Pharmacoinformatics Approach to Predict hERG Inhibition Potential of New Chemical Entities. Frontiers in Pharmacology, 9. ISSN 1663-9812 (Not OA)

Windley, Monique J and Lee, William and Vandenberg, Jamie I and Hill, Adam P (2018) The temperature dependence of kinetics associated with drug block of hERG channels are compound specific and an important factor for proarrhythmic risk prediction. Molecular Pharmacology, 94 (1). pp.760-769. ISSN 1521-0111 (PP OA)

Beattie, Kylie A and Hill, Adam P and Bardenet, Rémi and Cui, Yi and Vandenberg, Jamie I and Gavaghan, David J and de Boer, Teun P and Mirams, Gary R (2018) Sinusoidal voltage protocols for rapid characterisation of ion channel kinetics. Journal of Physiology, ePub. ISSN 00223751 (Not OA)

Lau, Carus and Hunter, Mark J and Stewart, Alastair and Perozo, Eduardo and Vandenberg, Jamie I (2018) Never at rest: insights into the conformational dynamics of ion channels from cryo-electron microscopy. Journal of Physiology, epub. ISSN 00223751 (Not OA)

Lee, William and Windley, Monique J and Vandenberg, Jamie I and Hill, Adam P (2017) In Vitro and In Silico Risk Assessment in Acquired Long QT Syndrome: The Devil Is in the Details. Frontiers in Physiology, 8. p. 934. ISSN 1664-042X (OA)

Vandenberg, Jamie I and Perozo, Eduardo and Allen, Toby W (2017) Towards a Structural View of Drug Binding to hERG K(+) Channels. Trends in Pharmacological Sciences, 38 (10). pp.899-907. ISSN 1873-3735 (PP OA)

Windley, Monique J and Abi-Gerges, Najah and Fermini, Bernard and Hancox, Jules C and Vandenberg, Jamie I and Hill, Adam P (2017) Measuring kinetics and potency of hERG block for CiPA. Journal of Pharmacological and Toxicological Methods, 87. pp.99-107. ISSN 1873-488X (PP OA)

Vandenberg, Jamie I and Perry, Matthew D and Hill, Adam P (2017) Recent advances in understanding and prevention of sudden cardiac death. F1000Research, 6. p. 1614. ISSN 2046-1402 (OA)

Phan, Kevin and Ng, Chai Ann and David, Erikka and Shishmarev, Dmitry and Kuchel, Philip W and Vandenberg, Jamie I and Perry, Matthew D (2017) The S1 Helix Critically Regulates the Finely-tuned Gating of Kv11.1 Channels. The Journal of Biological Chemistry, 292 (18). pp.7688-7705. ISSN 1083-351X (OA)

Chiamvimonvat, Nipavan and Chen-Izu, Ye and Clancy, Colleen E and Deschenes, Isabelle and Dobrev, Dobromir and Heijman, Jordi and Izu, Leighton and Qu, Zhilin and Ripplinger, Crystal M and Vandenberg, Jamie I and Weiss, James N and Koren, Gideon and Banyasz, Tamas and Grandi, Eleonora and Sanguinetti, Michael C and Bers, Donald M and Nerbonne, Jeanne M (2017) Potassium currents in the heart: Functional roles in repolarization, arrhythmia and therapeutics. The Journal of Physiology, 595 (7). pp.2229-2252. ISSN 1469-7793 (PP OA)

Grandi, Eleonora and Sanguinetti, Michael C and Bartos, Daniel C and Bers, Donald M and Chen-Izu, Ye and Chiamvimonvat, Nipavan and Colecraft, Henry M and Delisle, Brian P and Heijman, Jordi and Navedo, Manuel F and Noskov, Sergei and Proenza, Catherine and Vandenberg, Jamie I and Yarov-Yarovoy, Vladimir (2017) Potassium channels in the heart: structure, function and regulation. The Journal of Physiology, 595 (7). pp.2209-2228. ISSN 1469-7793 (PP OA)

Perry, Matthew D and Vandenberg, Jamie I (2016) TECRL: connecting sequence to consequence for a new sudden cardiac death gene. EMBO Molecular Medicine, 8. pp.1364-1365. ISSN 1757-4684 (OA)

Mann, Stefan A and Imtiaz, Mohammad and Winbo, Annika and Rydberg, Annika and Perry, Matthew D and Couderc, Jean-Philippe and Polonsky, Bronislava and McNitt, Scott and Zareba, Wojciech and Hill, Adam P and Vandenberg, Jamie I (2016) Convergence of models of human ventricular myocyte electrophysiology after global optimization to recapitulate clinical long QT phenotypes. Journal of Molecular and Cellular Cardiology, 100. pp.25-34. ISSN 1095-8584 (PP OA)

Immanuel, SA and Sadrieh, Arash and Baumert, Mathias and Couderc, Jean-Philippe and Zareba, Wojciech and Hill, Adam P and Vandenberg, Jamie I (2016) T-wave morphology can distinguish healthy controls from LQTS patients. Physiological Measurement, 37 (9). pp.1456-73. ISSN 1361-6579 (OA)

Ng, Chai-Ann and Gravel, Andrée E and Perry, Matthew D and Arnold, Alexandre A and Marcotte, Isabelle and Vandenberg, Jamie I (2016) Tyrosine residues from the S4-S5 linker of Kv11.1 channels are critical for slow deactivation. The Journal of Biological Chemistry, 291. pp.17293-17302. ISSN 1083-351X (OA)

Windley, Monique J and Mann, Stefan A and Vandenberg, Jamie I and Hill, Adam P (2016) Temperature effects on kinetics of Kv11.1 drug block have important consequences for in silico proarrhythmic risk prediction. Molecular Pharmacology, 90 (1). pp.1-11. ISSN 1521-0111 (OA)

Vandenberg, Jamie I and Hill, Adam P (2016) An 'alternans' way to quantify arrhythmogenic substrates. The Journal of Physiology, 594 (9). pp.2375-6. ISSN 1469-7793 (PMC OA)

Hodkinson, Emily C and Neijts, Melanie and Sadrieh, Arash and Imtiaz, Mohammad S and Baumert, Mathias and Subbiah, Rajesh N and Hayward, Christopher S and Boomsma, Dorret and Willemsen, Gonneke and Vandenberg, Jamie I and Hill, Adam P and De Geus, Eco (2016) Heritability of ECG Biomarkers in the Netherlands Twin Registry Measured from Holter ECGs. Frontiers in Physiology, 7. p. 154. ISSN 1664-042X (OA)

Christensen, Alex Hørby and Chatelain, Franck C and Huttner, Inken G and Olesen, Morten Salling and Soka, Magdalena and Feliciangeli, Sylvain and Horvat, Claire and Santiago, Celine F and Vandenberg, Jamie I and Schmitt, Nicole and Olesen, Søren-Peter and Lesage, Florian and Fatkin, Diane (2016) The two-pore domain potassium channel, TWIK-1, has a role in the regulation of heart rate and atrial size. Journal of Molecular and Cellular Cardiology, 97. pp.24-35. ISSN 1095-8584 (PP OA)

Hill, Adam P and Perry, Matthew D and Abi-Gerges, Najah and Couderc, Jean-Philippe and Fermini, Bernard and Hancox, Jules C and Knollmann, Bjorn C and Mirams, Gary R and Skinner, Jon and Zareba, Wojciech and Vandenberg, Jamie I (2016) Computational Cardiology and Risk Stratification for Sudden Cardiac Death: One of the Grand Challenges for Cardiology in the 21(st) Century. The Journal of Physiology, 594 (23). pp.6893-6908. ISSN 1469-7793 (OA)

Perry, Matthew D and Ng, Chai Ann and Phan, Kevin and David, E and Steer, K and Hunter, Mark J and Mann, Stefan A and Imtiaz, Mohammad S and Hill, Adam P and Ke, Ying and Vandenberg, Jamie I (2016) Rescue of protein expression defects may not be enough to abolish the pro-arrhythmic phenotype of long QT type 2 mutations. The Journal of Physiology, 594 (14). pp.4031-4049. ISSN 1469-7793 (PMC OA)

Heide, Juliane and Zhang, Fengyu and Bigos, Kristin L and Mann, Stefan A and Carr, Vaughan J and Shannon Weickert, Cynthia and Green, Melissa J and Weinberger, Daniel R and Vandenberg, Jamie I (2016) Differential Response to Risperidone in Schizophrenia Patients by KCNH2 Genotype and Drug Metabolizer Status. The American Journal of Psychiatry, 173 (1). pp.53-9. ISSN 1535-7228 (OA)

Lee, William and Mann, Stefan A and Windley, Monique J and Imtiaz, Mohammad S and Vandenberg, Jamie I and Hill, Adam P (2016) In silico assessment of kinetics and state dependent binding properties of drugs causing acquired LQTS. Progress in Biophysics and Molecular Biology, 120 (1-3). pp.89-99. ISSN 1873-1732 (Not OA)

Fermini, Bernard and Hancox, Jules C and Abi-Gerges, Najah and Bridgland-Taylor, Matthew and Chaudhary, Khuram W and Colatsky, Thomas and Correll, Krystle and Crumb, William and Damiano, Bruce and Erdemli, Gul and Gintant, Gary and Imredy, John and Koerner, John and Kramer, James and Levesque, Paul and Li, Zhihua and Lindqvist, Anders and Obejero-Paz, Carlos A and Rampe, David and Sawada, Kohei and Strauss, David G and Vandenberg, Jamie I (2016) A New Perspective in the Field of Cardiac Safety Testing through the Comprehensive In Vitro Proarrhythmia Assay Paradigm. Journal of Biomolecular Screening, 21 (1). pp.1-11. ISSN 1552-454X (PP OA)

Fonoudi, Hananeh and Ansari, Hassan and Abbasalizadeh, Saeed and Larijani, Mehran Rezaei and Kiani, Sahar and Hashemizadeh, Shiva and Zarchi, Ali Sharifi and Bosman, Alexis and Blue, Gillian M and Pahlavan, Sara and Perry, Matthew D and Orr, Yishay and Mayorchak, Yaroslav and Vandenberg, Jamie I and Talkhabi, Mahmood and Winlaw, David S and Harvey, Richard P and Aghdami, Nasser and Baharvand, Hossein (2015) A Universal and Robust Integrated Platform for the Scalable Production of Human Cardiomyocytes From Pluripotent Stem Cells. Stem Cells Translational Medicine, 4 (12). pp.1482-94. ISSN 2157-6564 (PP OA)

Perry, Matthew D and Ng, Chai-Ann and Mann, Stefan A and Sadrieh, Arash and Imtiaz, Mohammad and Hill, Adam P and Vandenberg, Jamie I (2015) Getting to the heart of hERG K(+) channel gating. The Journal of Physiology, 593 (12). pp.2575-85. ISSN 1469-7793 (PMC OA)

Heide, Juliane and Vandenberg, Jamie I and Weickert, CS (2015) Expression of Kcnh2-3.1 Mrna Is Increased in Small Neurons in the Dorsolateral Prefrontal Cortex in Patients with Schizophrenia. European Journal of Psychiatry, 29 (2). pp.85-103. ISSN (OA)

Martinac, Boris and Vandenberg, Jamie I (2015) 'Shooting gallery' for membrane proteins provides new insights into complexities of their function and structural dynamics. The Journal of Physiology, 593 (2). pp.353-4. ISSN 1469-7793 (PMC OA)

Vandenberg, Jamie I and Perry, Matthew D (2014) Can many subunits make light work of ion channel inactivation? The Journal of Physiology, 592 (Pt 20). pp.4411-2. ISSN 1469-7793 (OA)

Ng, Chai Ann and Phan, Kevin and Hill, Adam P and Vandenberg, Jamie I and Perry, Matthew D (2014) Multiple interactions between cytoplasmic domains regulate slow deactivation of Kv11.1 channels. The Journal of Biological Chemistry, 289 (37). pp.25822-32. ISSN 1083-351X (PMC OA)

Ke, Ying and Hunter, Mark J and Ng, Chai Ann and Perry, Matthew D and Vandenberg, Jamie I (2014) Role of the cytoplasmic N-terminal Cap and Per-Arnt-Sim (PAS) domain in trafficking and stabilization of Kv11.1 channels. The Journal of Biological Chemistry, 289 (20). pp.13782-91. ISSN 1083-351X (OA)

Hill, Adam P and Perrin, Mark J and Heide, Juliane and Campbell, Terence J and Mann, Stefan A and Vandenberg, Jamie I (2014) Kinetics of drug interaction with the Kv11.1 potassium channel. Molecular Pharmacology, 85 (5). pp.769-76. ISSN 1521-0111 (OA)

Hodkinson, Emily C and Hill, Adam P and Vandenberg, Jamie I (2014) The Romano-Ward syndrome--1964-2014: 50 years of progress. Irish Medical Journal, 107 (4). pp.122-4. ISSN 0332-3102 (PP OA)

Liang, Bo and Soka, Magdalena and Christensen, Alex Horby and Olesen, Morten S and Larsen, Anders P and Knop, Filip K and Wang, Fan and Nielsen, Jonas B and Andersen, Martin N and Humphreys, David T and Mann, Stefan A and Huttner, Inken G and Vandenberg, Jamie I and Svendsen, Jesper H and Haunsø, Stig and Preiss, Thomas and Seebohm, Guiscard and Olesen, Søren-Peter and Schmitt, Nicole and Fatkin, Diane (2014) Genetic variation in the two-pore domain potassium channel, TASK-1, may contribute to an atrial substrate for arrhythmogenesis. Journal of Molecular and Cellular Cardiology, 67. pp.69-76. ISSN 1095-8584 (PP OA)

Sadrieh, Arash and Domanski, Luke and Pitt-Francis, Joe and Mann, Stefan A and Hodkinson, Emily C and Ng, Chai-Ann and Perry, Matthew D and Taylor, John A and Gavaghan, David and Subbiah, Rajesh N and Vandenberg, Jamie I and Hill, Adam P (2014) Multiscale cardiac modelling reveals the origins of notched T waves in long QT syndrome type 2. Nature Communications, 5. p. 5069. ISSN 2041-1723 (OA)

Sadrieh, Arash and Mann, Stefan A and Subbiah, Rajesh N and Domanski, Luke and Taylor, John A and Vandenberg, Jamie I and Hill, Adam P (2013) Quantifying the origins of population variability in cardiac electrical activity through sensitivity analysis of the electrocardiogram. The Journal of physiology, 591 (Pt 17). pp.4207-22. ISSN 1469-7793 (PMC OA)

Perry, Matthew D and Wong, Sophia and Ng, Chai Ann and Vandenberg, Jamie I (2013) Hydrophobic interactions between the voltage sensor and pore mediate inactivation in Kv11.1 channels. The Journal of general physiology, 142 (3). pp.275-88. ISSN 1540-7748 (PMC OA)

Ke, Ying and Ng, Chai Ann and Hunter, Mark J and Mann, Stefan A and Heide, Juliane and Hill, Adam P and Vandenberg, Jamie I (2013) Trafficking defects in PAS domain mutant Kv11.1 channels: roles of reduced domain stability and altered domain-domain interactions. The Biochemical journal, 454 (1). pp.69-77. ISSN 1470-8728 (OA)

Huttner, Inken G and Trivedi, Gunjan and Jacoby, Arie and Mann, Stefan A and Vandenberg, Jamie I and Fatkin, Diane (2013) A transgenic zebrafish model of a human cardiac sodium channel mutation exhibits bradycardia, conduction-system abnormalities and early death. Journal of molecular and cellular cardiology, 61. pp.123-32. ISSN 1095-8584 (Not OA)

Perry, Matthew D and Ng, Chai Ann and Vandenberg, Jamie I (2013) Pore helices play a dynamic role as integrators of domain motion during Kv11.1 channel inactivation gating. The Journal of biological chemistry, 288 (16). pp.11482-91. ISSN 1083-351X (PMC OA)

Vandenberg, Jamie I and Conigrave, Arthur and King, Glenn F and Kirk, Kiaran (2013) From kinetics to imaging: an NMR odyssey-a festschrift symposium in honour of Philip William Kuchel. EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS, 42 (1). pp.1-2. ISSN 1432-1017 (OA)

Ng, Chai Ann and Torres, Allan M and Pagès, Guilhem and Kuchel, Philip W and Vandenberg, Jamie I (2013) Insights into hERG K+ channel structure and function from NMR studies. EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS, 42 (1). pp.71-9. ISSN 1432-1017 (Not OA)

Ng, Chai Ann and Ke, Ying and Perry, Matthew D and Tan, Peter S and Hill, Adam P and Vandenberg, Jamie I (2013) C-terminal β9-strand of the cyclic nucleotide-binding homology domain stabilizes activated states of Kv11.1 channels. PloS one, 8 (10). pp. e77032. ISSN 1932-6203 (Gold OA)

Mann, Stefan A and Castro, Maria L and Ohanian, Monique and Guo, Guanglan and Zodgekar, Poonam and Sheu, Angela and Stockhammer, Kathryn and Thompson, Tina and Playford, David and Subbiah, Rajesh and Kuchar, Dennis and Aggarwal, Anu and Vandenberg, Jamie I and Fatkin, Diane (2012) R222Q SCN5A mutation is associated with reversible ventricular ectopy and dilated cardiomyopathy. Journal of the American College of Cardiology, 60 (16). pp.1566-73. ISSN 1558-3597 (OA)

Tan, Peter S and Perry, Matthew D and Ng, Chai Ann and Vandenberg, Jamie I and Hill, Adam P (2012) Voltage-sensing domain mode shift is coupled to the activation gate by the N-terminal tail of hERG channels. The Journal of general physiology, 140 (3). pp.293-306. ISSN 1540-7748 (PMC OA)

Skinner, Jonathan R and Vandenberg, Jamie I (2012) Is medroxyprogesterone safe in women with long QT syndrome? Heart Rhythm, 9 (7). pp.1148-9. ISSN 1556-3871 (NOT OA)

Vandenberg, Jamie I and Perry, Matthew D and Perrin, Mark J and Mann, Stefan A and Ke, Ying and Hill, Adam P (2012) hERG K(+) channels: structure, function, and clinical significance. Physiological reviews, 92 (3). pp.1393-478. ISSN 1522-1210 (OA)

Vandenberg, Jamie I and Waxman, Stephen G (2012) Hodgkin and Huxley and the basis for electrical signalling: a remarkable legacy still going strong. The Journal of physiology, 590 (Pt 11). pp.2569-70. ISSN 1469-7793 (PMC OA)

Mann, Stefan A and Otway, Robyn and Guo, Guanglan and Soka, Magdalena and Karlsdotter, Lina and Trivedi, Gunjan and Ohanian, Monique and Zodgekar, Poonam and Smith, Robert A and Wouters, Merridee A and Subbiah, Rajesh and Walker, Bruce and Kuchar, Dennis and Sanders, Prashanthan and Griffiths, Lyn and Vandenberg, Jamie I and Fatkin, Diane (2012) Epistatic effects of potassium channel variation on cardiac repolarization and atrial fibrillation risk. Journal of the American College of Cardiology, 59 (11). pp.1017-25. ISSN 1558-3597 (OA)

Trevitt, Adam J and Reimers, Jeffrey R and Clarke, Ronald J and Vandenberg, Jamie I (2012) Biopyschem2011: A Joint Meeting of the Australian Society for Biophysics and the RAC1 Physical Chemistry Division Foreword. Australian Journal of Chemistry, 65 (5). pp.439-441. ISSN 0004-9425 (Not OA)

Ng, Chai Ann and Perry, Matthew D and Tan, Peter S and Hill, Adam P and Kuchel, Philip W and Vandenberg, Jamie I (2012) The S4-S5 linker acts as a signal integrator for HERG K+ channel activation and deactivation gating. PloS one, 7 (2). pp. e31640. ISSN 1932-6203 (Gold OA)

Heide, Juliane and Mann, Stefan A and Vandenberg, Jamie I (2012) The schizophrenia-associated Kv11.1-3.1 isoform results in reduced current accumulation during repetitive brief depolarizations. PloS one, 7 (9). pp. e45624. ISSN 1932-6203 (Gold OA)