Items where Author is "Hill, Adam P"

Article

Heitmann, Stewart and Vandenberg, Jamie I and Hill, Adam P (2023) Assessing drug safety by identifying the axis of arrhythmia in cardiomyocyte electrophysiology. eLife, 12. ISSN 2050-084X

Ballouz, Sara and Mangala, Melissa M and Perry, Matthew D and Heitmann, Stewart and Gillis, Jesse A and Hill, Adam P and Vandenberg, Jamie I (2021) Co-expression of calcium and hERG potassium channels reduces the incidence of proarrhythmic events. Cardiovascular Research, 117 (10). pp.2216-2227. ISSN 0008-6363

Ng, Chai-Ann and Farr, Jessica and Young, Paul and Windley, Monique J and Perry, Matthew D and Hill, Adam P and Vandenberg, Jamie I (2021) Heterozygous KCNH2 variant phenotyping using Flp-In HEK293 and high-throughput automated patch clamp electrophysiology. Biology Methods and Protocols, 6 (1). ISSN 2396-8923

Perry, Matthew D and Ng, Chai-Ann and Mangala, Melissa M and Ng, Timothy Y M and Hines, Adam D and Liang, Whitney and Xu, Michelle J O and Hill, Adam P and Vandenberg, Jamie I (2020) Pharmacological activation of IKr in models of long QT Type 2 risks overcorrection of repolarization. Cardiovascular Research, 116 (8). pp.1434-1445. ISSN 0008-6363

Holliday, Mira and Ross, Samantha Barratt and Lim, Seakcheng and Mangala, Melissa and Hill, Adam P and Szappanos, Henrietta Cserne and Hool, Livia and Semsarian, Christopher (2018) Development of induced pluripotent stem cells from a patient with hypertrophic cardiomyopathy who carries the pathogenic myosin heavy chain 7 mutation p.Arg403Gln. Stem Cell Research, 33. pp.269-273. ISSN 18735061 (Not OA)

Munawar, Saba and Windley, Monique J and Tse, Edwin G and Todd, Matthew H and Hill, Adam P and Vandenberg, Jamie I and Jabeen, Ishrat (2018) Experimentally Validated Pharmacoinformatics Approach to Predict hERG Inhibition Potential of New Chemical Entities. Frontiers in Pharmacology, 9. ISSN 1663-9812 (Not OA)

Windley, Monique J and Lee, William and Vandenberg, Jamie I and Hill, Adam P (2018) The temperature dependence of kinetics associated with drug block of hERG channels are compound specific and an important factor for proarrhythmic risk prediction. Molecular Pharmacology, 94 (1). pp.760-769. ISSN 1521-0111 (PP OA)

Beattie, Kylie A and Hill, Adam P and Bardenet, Rémi and Cui, Yi and Vandenberg, Jamie I and Gavaghan, David J and de Boer, Teun P and Mirams, Gary R (2018) Sinusoidal voltage protocols for rapid characterisation of ion channel kinetics. Journal of Physiology, ePub. ISSN 00223751 (Not OA)

Bavi, Navid and Martinac, Adam D and Cortes, D Marien and Bavi, Omid and Ridone, Pietro and Nomura, Takeshi and Hill, Adam P and Martinac, Boris and Perozo, Eduardo (2017) Structural Dynamics of the MscL C-terminal Domain. Scientific Reports, 7 (1). p. 17229. ISSN 2045-2322 (OA)

Lee, William and Windley, Monique J and Vandenberg, Jamie I and Hill, Adam P (2017) In Vitro and In Silico Risk Assessment in Acquired Long QT Syndrome: The Devil Is in the Details. Frontiers in Physiology, 8. p. 934. ISSN 1664-042X (OA)

Nikolova-Krstevski, Vesna and Wagner, Soeren and Yu, Ze Yan and Cox, Charles D and Cvetkovska, Jasmina and Hill, Adam P and Huttner, Inken G and Benson, Victoria and Werdich, Andreas A and MacRae, Calum and Feneley, Michael P and Friedrich, Oliver and Martinac, Boris and Fatkin, Diane (2017) Endocardial TRPC-6 Channels Act as Atrial Mechanosensors and Load-Dependent Modulators of Endocardial/Myocardial Cross-Talk. JACC: Basic to Translational Science, 2 (5). pp.575-590. ISSN 2452302X (PMC OA)

Windley, Monique J and Abi-Gerges, Najah and Fermini, Bernard and Hancox, Jules C and Vandenberg, Jamie I and Hill, Adam P (2017) Measuring kinetics and potency of hERG block for CiPA. Journal of Pharmacological and Toxicological Methods, 87. pp.99-107. ISSN 1873-488X (PP OA)

Vandenberg, Jamie I and Perry, Matthew D and Hill, Adam P (2017) Recent advances in understanding and prevention of sudden cardiac death. F1000Research, 6. p. 1614. ISSN 2046-1402 (OA)

Bavi, Navid and Bavi, Omid and Vossoughi, Manouchehr and Naghdabadi, Reza and Hill, Adam P and Martinac, Boris and Jamali, Yousef (2017) Nanomechanical properties of MscL alpha helices: A steered molecular dynamics study. Channels (Austin), 11 (3). pp.209-223. ISSN 1933-6969 (PMC OA)

Hill, Adam P (2017) Boosting the reserves: additive regulation of cardiac repolarisation. Journal of Physiology, 595 (7). pp.2269-2270. ISSN 1469-7793 (PP OA)

Mann, Stefan A and Imtiaz, Mohammad and Winbo, Annika and Rydberg, Annika and Perry, Matthew D and Couderc, Jean-Philippe and Polonsky, Bronislava and McNitt, Scott and Zareba, Wojciech and Hill, Adam P and Vandenberg, Jamie I (2016) Convergence of models of human ventricular myocyte electrophysiology after global optimization to recapitulate clinical long QT phenotypes. Journal of Molecular and Cellular Cardiology, 100. pp.25-34. ISSN 1095-8584 (PP OA)

Immanuel, SA and Sadrieh, Arash and Baumert, Mathias and Couderc, Jean-Philippe and Zareba, Wojciech and Hill, Adam P and Vandenberg, Jamie I (2016) T-wave morphology can distinguish healthy controls from LQTS patients. Physiological Measurement, 37 (9). pp.1456-73. ISSN 1361-6579 (OA)

Bavi, Navid and Cortes, D Marien and Cox, Charles D and Rohde, Paul R and Liu, Weihong and Deitmer, Joachim W and Bavi, Omid and Strop, Pavel and Hill, Adam P and Rees, Douglas and Corry, Ben and Perozo, Eduardo and Martinac, Boris (2016) The role of MscL amphipathic N terminus indicates a blueprint for bilayer-mediated gating of mechanosensitive channels. Nature Communications, 7. p. 11984. ISSN 2041-1723 (OA)

Windley, Monique J and Mann, Stefan A and Vandenberg, Jamie I and Hill, Adam P (2016) Temperature effects on kinetics of Kv11.1 drug block have important consequences for in silico proarrhythmic risk prediction. Molecular Pharmacology, 90 (1). pp.1-11. ISSN 1521-0111 (OA)

Vandenberg, Jamie I and Hill, Adam P (2016) An 'alternans' way to quantify arrhythmogenic substrates. The Journal of Physiology, 594 (9). pp.2375-6. ISSN 1469-7793 (PMC OA)

Hodkinson, Emily C and Neijts, Melanie and Sadrieh, Arash and Imtiaz, Mohammad S and Baumert, Mathias and Subbiah, Rajesh N and Hayward, Christopher S and Boomsma, Dorret and Willemsen, Gonneke and Vandenberg, Jamie I and Hill, Adam P and De Geus, Eco (2016) Heritability of ECG Biomarkers in the Netherlands Twin Registry Measured from Holter ECGs. Frontiers in Physiology, 7. p. 154. ISSN 1664-042X (OA)

Hill, Adam P and Perry, Matthew D and Abi-Gerges, Najah and Couderc, Jean-Philippe and Fermini, Bernard and Hancox, Jules C and Knollmann, Bjorn C and Mirams, Gary R and Skinner, Jon and Zareba, Wojciech and Vandenberg, Jamie I (2016) Computational Cardiology and Risk Stratification for Sudden Cardiac Death: One of the Grand Challenges for Cardiology in the 21(st) Century. The Journal of Physiology, 594 (23). pp.6893-6908. ISSN 1469-7793 (OA)

Perry, Matthew D and Ng, Chai Ann and Phan, Kevin and David, E and Steer, K and Hunter, Mark J and Mann, Stefan A and Imtiaz, Mohammad S and Hill, Adam P and Ke, Ying and Vandenberg, Jamie I (2016) Rescue of protein expression defects may not be enough to abolish the pro-arrhythmic phenotype of long QT type 2 mutations. The Journal of Physiology, 594 (14). pp.4031-4049. ISSN 1469-7793 (PMC OA)

Lee, William and Mann, Stefan A and Windley, Monique J and Imtiaz, Mohammad S and Vandenberg, Jamie I and Hill, Adam P (2016) In silico assessment of kinetics and state dependent binding properties of drugs causing acquired LQTS. Progress in Biophysics and Molecular Biology, 120 (1-3). pp.89-99. ISSN 1873-1732 (Not OA)

Chaudhuri, Rima and Sadrieh, Arash and Hoffman, Nolan J and Parker, Benjamin L and Humphrey, Sean J and Stöckli, Jacqueline and Hill, Adam P and James, David E and Yang, Jean Yee Hwa (2015) PhosphOrtholog: a web-based tool for cross-species mapping of orthologous protein post-translational modifications. BMC Genomics, 16. p. 617. ISSN 1471-2164 (OA)

Perry, Matthew D and Ng, Chai-Ann and Mann, Stefan A and Sadrieh, Arash and Imtiaz, Mohammad and Hill, Adam P and Vandenberg, Jamie I (2015) Getting to the heart of hERG K(+) channel gating. The Journal of Physiology, 593 (12). pp.2575-85. ISSN 1469-7793 (PMC OA)

Ng, Chai Ann and Phan, Kevin and Hill, Adam P and Vandenberg, Jamie I and Perry, Matthew D (2014) Multiple interactions between cytoplasmic domains regulate slow deactivation of Kv11.1 channels. The Journal of Biological Chemistry, 289 (37). pp.25822-32. ISSN 1083-351X (PMC OA)

Hill, Adam P and Perrin, Mark J and Heide, Juliane and Campbell, Terence J and Mann, Stefan A and Vandenberg, Jamie I (2014) Kinetics of drug interaction with the Kv11.1 potassium channel. Molecular Pharmacology, 85 (5). pp.769-76. ISSN 1521-0111 (OA)

Hodkinson, Emily C and Hill, Adam P and Vandenberg, Jamie I (2014) The Romano-Ward syndrome--1964-2014: 50 years of progress. Irish Medical Journal, 107 (4). pp.122-4. ISSN 0332-3102 (PP OA)

Sadrieh, Arash and Domanski, Luke and Pitt-Francis, Joe and Mann, Stefan A and Hodkinson, Emily C and Ng, Chai-Ann and Perry, Matthew D and Taylor, John A and Gavaghan, David and Subbiah, Rajesh N and Vandenberg, Jamie I and Hill, Adam P (2014) Multiscale cardiac modelling reveals the origins of notched T waves in long QT syndrome type 2. Nature Communications, 5. p. 5069. ISSN 2041-1723 (OA)

Sadrieh, Arash and Mann, Stefan A and Subbiah, Rajesh N and Domanski, Luke and Taylor, John A and Vandenberg, Jamie I and Hill, Adam P (2013) Quantifying the origins of population variability in cardiac electrical activity through sensitivity analysis of the electrocardiogram. The Journal of physiology, 591 (Pt 17). pp.4207-22. ISSN 1469-7793 (PMC OA)

Ke, Ying and Ng, Chai Ann and Hunter, Mark J and Mann, Stefan A and Heide, Juliane and Hill, Adam P and Vandenberg, Jamie I (2013) Trafficking defects in PAS domain mutant Kv11.1 channels: roles of reduced domain stability and altered domain-domain interactions. The Biochemical journal, 454 (1). pp.69-77. ISSN 1470-8728 (OA)

Ng, Chai Ann and Ke, Ying and Perry, Matthew D and Tan, Peter S and Hill, Adam P and Vandenberg, Jamie I (2013) C-terminal β9-strand of the cyclic nucleotide-binding homology domain stabilizes activated states of Kv11.1 channels. PloS one, 8 (10). pp. e77032. ISSN 1932-6203 (Gold OA)

Sadrieh, Arash and Charissis, Stefan and Hill, Adam P (2013) An On-chip Heterogeneous Implementation of a General Sparse Linear Solver. Parallel and Distributed Processing Symposium Workshops & PhD Forum (IPDPSW), 2013 IEEE 27th International. pp.54-63. ISSN 978-0-7695-4979-8 (OA)

Tan, Peter S and Perry, Matthew D and Ng, Chai Ann and Vandenberg, Jamie I and Hill, Adam P (2012) Voltage-sensing domain mode shift is coupled to the activation gate by the N-terminal tail of hERG channels. The Journal of general physiology, 140 (3). pp.293-306. ISSN 1540-7748 (PMC OA)

Vandenberg, Jamie I and Perry, Matthew D and Perrin, Mark J and Mann, Stefan A and Ke, Ying and Hill, Adam P (2012) hERG K(+) channels: structure, function, and clinical significance. Physiological reviews, 92 (3). pp.1393-478. ISSN 1522-1210 (OA)

Ng, Chai Ann and Perry, Matthew D and Tan, Peter S and Hill, Adam P and Kuchel, Philip W and Vandenberg, Jamie I (2012) The S4-S5 linker acts as a signal integrator for HERG K+ channel activation and deactivation gating. PloS one, 7 (2). pp. e31640. ISSN 1932-6203 (Gold OA)