Prognostic Biomarkers in Early-stage Gastric Adenocarcinoma Treated With Adjuvant Chemoradiotherapy

PECTASIDES, EIRINI and CHATZIDAKIS, IOANNIS and KOTOULA, VASSILIKI and KOLIOU, GEORGIA-ANGELIKI and PAPADOPOULOU, KYRIAKI and GIANNOULATOU, ELENI and GIANNOUZAKOS, VASILIOS G. and BOBOS, MATTHEOS and PAPAVASILEIOU, CHRISTOS and CHRISAFI, SOFIA and FLOROU, AIKATERINI and PECTASIDES, DIMITRIOS and FOUNTZILAS, GEORGE (2020) Prognostic Biomarkers in Early-stage Gastric Adenocarcinoma Treated With Adjuvant Chemoradiotherapy. Cancer Genomics - Proteomics, 17 (3). pp.277-290. ISSN 1109-6535

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Link to published document: http://doi.org/10.21873/cgp.20188

Abstract

Background/aim: Early-stage gastric cancer has a high risk of recurrence, despite trimodality therapy with surgery, chemotherapy and radiation. To improve patient selection for adjuvant chemoradiotherapy, we evaluated the prognostic significance of immunohistochemical and genetic biomarkers in patients with resected gastric adenocarcinoma. Patients and methods: Tumors from 119 patients were subjected to immunohistochemistry for 12 protein biomarkers, as well as next-generation sequencing. Clinical and biomarker data were available for 91 patients. Results: EBV-positive tumors and tumors with mutations had higher intratumoral CD8 tumor-infiltrating lymphocyte density (p=0.009 and p=0.017, respectively). PIK3CA mutations were correlated with VEGFA overexpression (p=0.042), while KRAS mutations and HER2 expression were mutually exclusive (p=0.036). PTEN expression univariately confirmed longer overall survival (HR=0.27; p=0.046), while there was a trend between the presence of KRAS mutations and inferior disease-free and overall survival. Conclusion: PTEN protein expression and KRAS mutations may predict disease outcome in early-stage gastric cancer. These results need to be further validated in larger cohorts.

Item Type: Article
Subjects: R Medicine > R Medicine (General)
Depositing User: Repository Administrator
Date Deposited: 02 Jun 2020 03:09
Last Modified: 19 Oct 2021 00:35
URI: http://eprints.victorchang.edu.au/id/eprint/969

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