Myocardial Interstitial Fibrosis in Nonischemic Heart Disease, Part 3/4

Díez, Javier and González, Arantxa and Kovacic, Jason C. (2020) Myocardial Interstitial Fibrosis in Nonischemic Heart Disease, Part 3/4. Journal of the American College of Cardiology, 75 (17). pp.2204-2218. ISSN 07351097

[img]
Preview
Text
Myocardial-Interstitial-Fibrosis-in-Nonischemic-Heart-Disease-Part-34-JACC-Focus-SeminarJournal-of-the-American-College-of-Cardiology.pdf
Available under License Creative Commons Attribution Non-commercial No Derivatives.

Download (2MB) | Preview
Link to published document: http://doi.org/10.1016/j.jacc.2020.03.019

Abstract

Myocardial interstitial fibrosis (MIF) is a histological hallmark of several cardiac diseases that alter myocardial architecture and function and are associated with progression to heart failure. MIF is a diffuse and patchy process, appearing as a combination of interstitial microscars, perivascular collagen fiber deposition, and increased thickness of mysial collagen strands. Although MIF arises mainly because of alterations in fibrillar collagen turnover leading to collagen fiber accumulation, there are also alterations in other nonfibrillar extracellular matrix components, such as fibronectin and matricellular proteins. Furthermore, in addition to an excess of collagen, qualitative changes in collagen fibers also contribute to the detrimental impact of MIF. In this part 3 of a 4-part JACC Focus Seminar, we review the evidence on the complex mechanisms leading to MIF, as well as its contribution to systolic and diastolic cardiac dysfunction and impaired clinical outcomes in patients with nonischemic heart disease.

Item Type: Article
Subjects: R Medicine > R Medicine (General)
Depositing User: Repository Administrator
Date Deposited: 02 Jun 2020 03:03
Last Modified: 12 Oct 2021 03:21
URI: http://eprints.victorchang.edu.au/id/eprint/966

Actions (login required)

View Item View Item