Extracellular Matrix in Ischemic Heart Disease, Part 4/4

Frangogiannis, Nikolaos G. and Kovacic, Jason C. (2020) Extracellular Matrix in Ischemic Heart Disease, Part 4/4. Journal of the American College of Cardiology, 75 (17). pp.2219-2235. ISSN 07351097

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Link to published document: http://doi.org/10.1016/j.jacc.2020.03.020


Myocardial ischemia and infarction, both in the acute and chronic phases, are associated with cardiomyocyte loss and dramatic changes in the cardiac extracellular matrix (ECM). It has long been appreciated that these changes in the cardiac ECM result in altered mechanical properties of ischemic or infarcted myocardial segments. However, a growing body of evidence now clearly demonstrates that these alterations of the ECM not only affect the structural properties of the ischemic and post-infarct heart, but they also play a crucial and sometimes direct role in mediating a range of biological pathways, including the orchestration of inflammatory and reparative processes, as well as the pathogenesis of adverse remodeling. This final part of a 4-part JACC Focus Seminar reviews the evidence on the role of the ECM in relation to the ischemic and infarcted heart, as well as its contribution to cardiac dysfunction and adverse clinical outcomes.

Item Type: Article
Subjects: R Medicine > R Medicine (General)
Depositing User: Repository Administrator
Date Deposited: 02 Jun 2020 02:35
Last Modified: 14 Oct 2021 04:29
URI: http://eprints.victorchang.edu.au/id/eprint/965

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