NIKOLAIDI, ADAMANTIA and KOTOULA, VASSILIKI and KOLIOU, GEORGIA-ANGELIKI and GIANNOULATOU, ELENI and PAPADOPOULOU, KYRIAKI and ZAGOURI, FLORA and PENTHEROUDAKIS, GEORGE and GOGAS, HELEN and BOBOS, MATTHEOS and CHATZOPOULOS, KYRIAKOS and OIKONOMOPOULOS, GEORGIOS and PECTASIDES, DIMITRIOS and SALOUSTROS, EMMANOUIL and ARNOGIANNAKI, NIKI and NICOLAOU, IRENE and PAPAKOSTAS, PAVLOS and BOMPOLAKI, ILIADA and ARAVANTINOS, GERASIMOS and ATHANASIADIS, ILIAS and FOUNTZILAS, GEORGE (2020) Tumor Mutational Patterns and Infiltrating Lymphocyte Density in Young and Elderly Patients With Breast Cancer. Cancer Genomics - Proteomics, 17 (2). pp.181-193. ISSN 1109-6535
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Abstract
BACKGROUND/AIM:
Age may pertain to different tumor genotype characteristics which may interfere with treatment efficacy and prognosis. We investigated the distribution and prognostic effect of mutations and tumor infiltrating lymphocyte (stromal TIL density) in young (≤35 years) and elderly (>65 years) early breast cancer patients.
MATERIALS AND METHODS:
Paraffin tumor genotypes of all clinical subtypes from 345 patients were examined.
RESULTS:
A total of 638 mutations were detected in 221 patients (64.1%). Compared to young, elderly patients presented with lower TIL density (p<0.001) but more TILs in TP53 mutated tumors (p=0.042). Mutation in one, rather than in 2 or more genes, conferred better outcome (DFS: HR=0.51, p=0.016; OS: HR=0.47, p=0.015) but the effect was age-independent.
CONCLUSION:
There are fewer TILs and different mutations patterns in tumors from elderly patients compared to young. Age and TIL-independent gene agnostic co-mutations affect patient outcome.
Copyright© 2020, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.
| Item Type: | Article |
|---|---|
| Subjects: | R Medicine > R Medicine (General) |
| Divisions: | Faculty of Medicine, Health and Life Sciences > School of Medicine |
| Depositing User: | Repository Administrator |
| Date Deposited: | 10 Mar 2020 05:03 |
| Last Modified: | 18 Oct 2021 05:20 |
| URI: | https://eprints.victorchang.edu.au/id/eprint/943 |
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