Generation of VCCRIi001-A, a human induced pluripotent stem cell line, from a patient with spontaneous coronary artery dissection

Mishra, Ketan and Junday, Keerat and Wong, Claire M.Y. and Chan, Andrea Y. and Hesselson, Stephanie and Muller, David W. and Iismaa, Siiri E. and Mehta, Ashish and Graham, Robert M. (2019) Generation of VCCRIi001-A, a human induced pluripotent stem cell line, from a patient with spontaneous coronary artery dissection. Stem Cell Research, 41. p. 101584. ISSN 18735061

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Link to published document: http://doi.org/10.1016/j.scr.2019.101584

Abstract

Spontaneous coronary artery dissection (SCAD) is a non-atherosclerotic form of coronary artery disease of unknown cause that predominantly affects women (>90%; mean age 44-55 years) and can be fatal. The finding of familial clustering, including the concordant involvement of monozygotic twins, and its association with the PHACTR1/EDN1 genetic locus, indicate a genetic predisposition to its pathophysiology. A human induced pluripotent stem cell line (hiPSC) was generated from a patient who had survived an episode of SCAD. This disease-specific hiPSC line will be useful for the study of SCAD after differentiation into blood vessel-forming cells.

Item Type: Article
Subjects: R Medicine > R Medicine (General)
Depositing User: Repository Administrator
Date Deposited: 19 Nov 2019 22:36
Last Modified: 19 Nov 2019 22:36
URI: https://eprints.victorchang.edu.au/id/eprint/868

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