Luthra, Ansha and Langley, David B. and Schofield, Peter and Jackson, Jennifer and Abdelatti, Mahmoud and Rouet, Romain and Nevoltris, Damien and Mazigi, Ohan and Crossett, Ben and Christie, Mary and Christ, Daniel (2019) Human Antibody Bispecifics through Phage Display Selection. Biochemistry, ePub. ISSN 0006-2960 (N/A)
Full text not available from this repository.Abstract
We developed a repertoire approach to generate human antibody bispecifics. Using phage display selection of antibody heavy chains in the presence of a competitor light chain and providing a cognate light chain with an affinity handle, we identified mutations that prevent heavy/light chain mispairing. The strategy allows for the selection of human antibody chains that autonomously assemble into bispecifics.
| Item Type: | Article |
|---|---|
| Subjects: | R Medicine > R Medicine (General) |
| Depositing User: | Repository Administrator |
| Date Deposited: | 24 Mar 2019 22:28 |
| Last Modified: | 24 Mar 2019 22:28 |
| URI: | https://eprints.victorchang.edu.au/id/eprint/817 |
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