Host and microbiome multi-omics integration: applications and methodologies

Wang, Qing and Wang, Kaicen and Wu, Wenrui and Giannoulatou, Eleni and Ho, Joshua W K and Li, Lanjuan (2019) Host and microbiome multi-omics integration: applications and methodologies. Biophysical Reviews. ISSN 1867-2450 (Not OA)

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Link to published document: http://doi.org/10.1007/s12551-018-0491-7

Abstract

The study of the microbial community-the microbiome-associated with a human host is a maturing research field. It is increasingly clear that the composition of the human's microbiome is associated with various diseases such as gastrointestinal diseases, liver diseases and metabolic diseases. Using high-throughput technologies such as next-generation sequencing and mass spectrometry-based metabolomics, we are able to comprehensively sequence the microbiome-the metagenome-and associate these data with the genomic, epigenomics, transcriptomic and metabolic profile of the host. Our review summarises the application of integrating host omics with microbiome as well as the analytical methods and related tools applied in these studies. In addition, potential future directions are discussed.

Item Type: Article
Additional Information: Post print on file
Subjects: R Medicine > R Medicine (General)
Depositing User: Repository Administrator
Date Deposited: 16 Jan 2019 02:12
Last Modified: 20 Jan 2019 22:27
URI: https://eprints.victorchang.edu.au/id/eprint/786

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