Nikolova-Krstevski, Vesna and Wagner, Soeren and Yu, Ze Yan and Cox, Charles D and Cvetkovska, Jasmina and Hill, Adam P and Huttner, Inken G and Benson, Victoria and Werdich, Andreas A and MacRae, Calum and Feneley, Michael P and Friedrich, Oliver and Martinac, Boris and Fatkin, Diane (2017) Endocardial TRPC-6 Channels Act as Atrial Mechanosensors and Load-Dependent Modulators of Endocardial/Myocardial Cross-Talk. JACC: Basic to Translational Science, 2 (5). pp.575-590. ISSN 2452302X (PMC OA)
Nikolova-Krstevski, Vesna and Wagner, Soeren and Yu, Ze Yan and Cox, Charles D and Cvetkovska, Jasmina and Hill, Adam P and Huttner, Inken G and Benson, Victoria and Werdich, Andreas A and MacRae, Calum and Feneley, Michael P and Friedrich, Oliver and Martinac, Boris and Fatkin, Diane (2017) Endocardial TRPC-6 Channels Act as Atrial Mechanosensors and Load-Dependent Modulators of Endocardial/Myocardial Cross-Talk. JACC: Basic to Translational Science, 2 (5). pp.575-590. ISSN 2452302X (PMC OA)
Nikolova-Krstevski, Vesna and Wagner, Soeren and Yu, Ze Yan and Cox, Charles D and Cvetkovska, Jasmina and Hill, Adam P and Huttner, Inken G and Benson, Victoria and Werdich, Andreas A and MacRae, Calum and Feneley, Michael P and Friedrich, Oliver and Martinac, Boris and Fatkin, Diane (2017) Endocardial TRPC-6 Channels Act as Atrial Mechanosensors and Load-Dependent Modulators of Endocardial/Myocardial Cross-Talk. JACC: Basic to Translational Science, 2 (5). pp.575-590. ISSN 2452302X (PMC OA)
Abstract
Mechanoelectrical feedback may increase arrhythmia susceptibility, but the molecular mechanisms are incompletely understood. This study showed that mechanical stretch altered the localization, protein levels, and function of the cation-selective transient receptor potential channel (TRPC)-6 in atrial endocardial cells in humans, pigs, and mice. In endocardial/myocardial cross-talk studies, addition of media from porcine atrial endocardium (AE) cells altered the calcium (Ca2+) transient characteristics of human-induced pluripotent stem cell-derived cardiomyocytes. These changes did not occur with media from stretched AE cells. Our data suggested that endocardial TRPC-6-dependent paracrine signaling may modulate myocardial Ca2+ homeostasis under basal conditions and protect against stretch-induced atrial arrhythmias.
Metadata
| Additional Information: | This article is available for free from the PMC website: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6058914/ |
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| Subjects: | R Medicine > R Medicine (General) |
| Depositing User: | Repository Administrator |
| Date Deposited: | 05 Aug 2018 23:54 |
| Last Modified: | 05 Aug 2018 23:54 |