Zardoya-Laguardia, Pablo and Blaschitz, Astrid and Hirschmugl, Birgit and Lang, Ingrid and Herzog, Sereina A and Nikitina, Liudmila and Gauster, Martin and Häusler, Martin and Cervar-Zivkovic, Mila and Karpf, Eva and Maghzal, Ghassan J and Stanley, Chris P and Stocker, Roland and Wadsack, Christian and Frank, Saša and Sedlmayr, Peter (2018) Endothelial indoleamine 2,3-dioxygenase-1 regulates the placental vascular tone and is deficient in intrauterine growth restriction and pre-eclampsia. Scientific Reports, 8 (1). p. 5488. ISSN 2045-2322 (Not OA)
Full text not available from this repository.Abstract
Indoleamine 2,3-dioxygenase-1 (IDO1) mediates the degradation of L-tryptophan (L-Trp) and is constitutively expressed in the chorionic vascular endothelium of the human placenta with highest levels in the microvasculature. Given that endothelial expression of IDO1 has been shown to regulate vascular tone and blood pressure in mice under the condition of systemic inflammation, we asked whether IDO1 is also involved in the regulation of placental blood flow and if yes, whether this function is potentially impaired in intrauterine growth restriction (IUGR) and pre-eclampsia (PE). In the large arteries of the chorionic plate L-Trp induced relaxation only after upregulation of IDO1 using interferon gamma and tumor necrosis factor alpha. However, ex vivo placental perfusion of pre-constricted cotyledonic vasculature with L-Trp decreases the vessel back pressure without prior IDO1 induction. Further to this finding, IDO1 protein expression and activity is reduced in IUGR and PE when compared to gestational age-matched control tissue. These data suggest that L-Trp catabolism plays a role in the regulation of placental vascular tone, a finding which is potentially linked to placental and fetal growth. In this context our data suggest that IDO1 deficiency is related to the pathogenesis of IUGR and PE.
| Item Type: | Article |
|---|---|
| Subjects: | Q Science > Q Science (General) |
| Depositing User: | Repository Administrator |
| Date Deposited: | 09 Apr 2018 00:06 |
| Last Modified: | 09 Apr 2018 00:06 |
| URI: | https://eprints.victorchang.edu.au/id/eprint/716 |
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