Iismaa, Siiri E and Kaidonis, Xenia and Nicks, Amy and Bogush, Nikolay and Kikuchi, Kazu and Naqvi, Nawazish and Harvey, Richard P and Husain, Ahsan and Graham, Robert M (2018) Comparative regenerative mechanisms across different mammalian tissues. npj Regenerative Medicine, 3 (1). ISSN 2057-3995 (OA)
Iismaa, Siiri E and Kaidonis, Xenia and Nicks, Amy and Bogush, Nikolay and Kikuchi, Kazu and Naqvi, Nawazish and Harvey, Richard P and Husain, Ahsan and Graham, Robert M (2018) Comparative regenerative mechanisms across different mammalian tissues. npj Regenerative Medicine, 3 (1). ISSN 2057-3995 (OA)
Iismaa, Siiri E and Kaidonis, Xenia and Nicks, Amy and Bogush, Nikolay and Kikuchi, Kazu and Naqvi, Nawazish and Harvey, Richard P and Husain, Ahsan and Graham, Robert M (2018) Comparative regenerative mechanisms across different mammalian tissues. npj Regenerative Medicine, 3 (1). ISSN 2057-3995 (OA)
Abstract
Stimulating regeneration of complex tissues and organs after injury to effect complete structural and functional repair, is an attractive therapeutic option that would revolutionize clinical medicine. Compared to many metazoan phyla that show extraordinary regenerative capacity, which in some instances persists throughout life, regeneration in mammalians, particularly humans, is limited or absent. Here we consider recent insights in the elucidation of molecular mechanisms of regeneration that have come from studies of tissue homeostasis and injury repair in mammalian tissues that span the spectrum from little or no self-renewal, to those showing active cell turnover throughout life. These studies highlight the diversity of factors that constrain regeneration, including immune responses, extracellular matrix composition, age, injury type, physiological adaptation, and angiogenic and neurogenic capacity. Despite these constraints, much progress has been made in elucidating key molecular mechanisms that may provide therapeutic targets for the development of future regenerative therapies, as well as previously unidentified developmental paradigms and windows-of-opportunity for improved regenerative repair.
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Additional Information: | Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons. org/licenses/by/4.0/. |
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Subjects: | R Medicine > R Medicine (General) |
Depositing User: | Repository Administrator |
Date Deposited: | 19 Mar 2018 04:17 |
Last Modified: | 05 Apr 2018 22:40 |
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