Mouat, Margaret A and Coleman, James L J and Smith, Nicola J (2018) GPCRS IN CONTEXT: SEXUAL DIMORPHISM IN THE CARDIOVASCULAR SYSTEM. British Journal of Pharmacology, 175. pp.4047-4059. ISSN 00071188 (PP OA)
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Abstract
Cardiovascular disease remains the largest cause of mortality worldwide and there is a clear gender gap in disease occurrence: men are predisposed to earlier onset of cardiovascular disease, including atherosclerosis and hypertension, than are women. Oestrogen may be a driving factor for female-specific cardioprotection, though androgens and sex chromosomes are also likely to contribute to sexual dimorphism in the cardiovascular system. Many G protein-coupled receptor (GPCR)-mediated processes are involved in cardiovascular homeostasis and some exhibit clear sex-divergence. Here we focus on the G protein-coupled oestrogen receptor, endothelin receptors ETA and ETB , and the eicosanoid GPCRs, discussing the evidence and potential mechanisms leading to gender dimorphic responses in the vasculature. Use of animal models and pharmacological tools has been essential to understanding the role of these receptors in the cardiovascular system, and will be key to further delineating their sex-specific effects. Ultimately, this may illuminate wider sex differences in cardiovascular pathology and physiology.
| Item Type: | Article |
|---|---|
| Subjects: | R Medicine > R Medicine (General) |
| Depositing User: | Repository Administrator |
| Date Deposited: | 09 Mar 2018 03:42 |
| Last Modified: | 13 Jan 2019 21:14 |
| URI: | https://eprints.victorchang.edu.au/id/eprint/696 |
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