Sugimoto, Kotaro and Hui, Subhra P and Sheng, Delicia Z and Nakayama, Maki and Kikuchi, Kazu (2017) Zebrafish FOXP3 is required for the maintenance of immune tolerance. Developmental and Comparative Immunology, 73. pp.156-162. ISSN 1879-0089 (Not OA)
Full text not available from this repository.Abstract
Regulatory T (Treg) cells play a central role in the suppression of excessive immune responses against both self and non-self antigens. The development and function of Treg cells are controlled by a master regulatory gene encoding the forkhead box P3 (FOXP3) protein in mammals. However, little is known regarding the functions of Treg cells and FOXP3 in non-mammalian vertebrates. In this study, we generated mutant zebrafish lacking a functional FOXP3 ortholog, and demonstrated a significant reduction in survival accompanied by a marked increase in inflammatory gene expression, mononuclear cell infiltration, and T cell proliferation in peripheral tissues. Our findings indicate that the zebrafish FOXP3 protein may have an evolutionally conserved role in the control of immune tolerance, illuminating the potential of the zebrafish as a novel model for investigating the development and functions of Treg cells.
| Item Type: | Article |
|---|---|
| Subjects: | R Medicine > R Medicine (General) |
| Depositing User: | Repository Administrator |
| Date Deposited: | 04 Apr 2017 22:33 |
| Last Modified: | 04 Apr 2017 22:33 |
| URI: | https://eprints.victorchang.edu.au/id/eprint/578 |
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