Teng, Nathaniel and Maghzal, Ghassan J and Talib, Jihan and Rashid, Imran and Lau, Antony K and Stocker, Roland (2017) The roles of myeloperoxidase in coronary artery disease and its potential implication in plaque rupture. Redox Report: Communications in Free Radical Research, 22 (2). pp.51-73. ISSN 1743-2928 (OA)
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Abstract
Atherosclerosis is the main pathophysiological process underlying coronary artery disease (CAD). Acute complications of atherosclerosis, such as myocardial infarction, are caused by the rupture of vulnerable atherosclerotic plaques, which are characterized by thin, highly inflamed, and collagen-poor fibrous caps. Several lines of evidence mechanistically link the heme peroxidase myeloperoxidase (MPO), inflammation as well as acute and chronic manifestations of atherosclerosis. MPO and MPO-derived oxidants have been shown to contribute to the formation of foam cells, endothelial dysfunction and apoptosis, the activation of latent matrix metalloproteinases, and the expression of tissue factor that can promote the development of vulnerable plaque. As such, detection, quantification and imaging of MPO mass and activity have become useful in cardiac risk stratification, both for disease assessment and in the identification of patients at risk of plaque rupture. This review summarizes the current knowledge about the role of MPO in CAD with a focus on its possible roles in plaque rupture and recent advances to quantify and image MPO in plasma and atherosclerotic plaques.
| Item Type: | Article |
|---|---|
| Additional Information: | EPUB NOV 2016 is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License ( http://creativecommons.org/licenses/by- nc-nd/4.0/ ), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way |
| Subjects: | R Medicine > R Medicine (General) |
| Depositing User: | Repository Administrator |
| Date Deposited: | 30 Nov 2016 04:53 |
| Last Modified: | 28 Sep 2017 06:10 |
| URI: | https://eprints.victorchang.edu.au/id/eprint/519 |
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