Nadel, James and O'Dwyer, Eoin and Emmanuel, Sam and Huang, Justyn and Cheruvu, Sarat and Sammel, Neville and Brew, Bruce and Otton, James and Holloway, Cameron J (2016) High-risk coronary plaque, invasive coronary procedures, and cardiac events among HIV-positive individuals and matched controls. Journal of Cardiovascular Computed Tomography, 10 (5). pp.391-397. ISSN 1876-861X (N/A)
Full text not available from this repository.Abstract
BACKGROUND
Human immunodeficiency virus (HIV) infection is considered a chronic, treatable disease, although treatment is associated with increased rates of coronary artery disease (CAD). We analyzed the utility of coronary CTA in the assessment of CAD among HIV patients and explored whether HIV patients are at greater risk of associated morbidity and mortality compared to HIV-negative controls.
METHODS
In a retrospective, single center cohort study 97 males without history of previous coronary artery disease who had undergone coronary CTA between 2011 and 2014 was analyzed, including 32 HIV positive patients and 65 matched HIV negative controls. Presence and composition of coronary plaque was determined by coronary CTA. Data on subsequent coronary events and coronary intervention was collected.
RESULTS
Patients with HIV had higher rates of non-calcified plaque (0.8 ± 1.5 versus 0.3 ± 0.7, p = 0.03) compared to negative controls. At a median follow-up of 38 months, patients with HIV were at greater risk of non-ST elevation acute coronary syndrome (16% versus 3%, p < 0.04), although there was no difference in the combined endpoint of all acute coronary syndromes (19% versus 6%, p = 0.08). Following baseline coronary TCA, there was a higher rate of coronary intervention in patients without HIV (mean time to event 9.9 ± 3.3 versus 20.6 ± 4.9 months, p < 0.04).
CONCLUSION
Patients with HIV more pronounces coronary atherosclerosis on coronary CTA and higher rates of non-ST elevation acute coronary syndromes compared to negative controls.
| Item Type: | Article |
|---|---|
| Additional Information: | Published: July 2016 |
| Subjects: | R Medicine > R Medicine (General) |
| Depositing User: | Repository Administrator |
| Date Deposited: | 22 Aug 2016 04:34 |
| Last Modified: | 17 Jan 2018 06:16 |
| URI: | https://eprints.victorchang.edu.au/id/eprint/478 |
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