Mustapic, Mislav and Hossain, Md Shahriar Al and Horvat, Joseph and Wagner, Pawel and Mitchell, David R.G. and Kim, Jung Ho and Alici, Gursel and Nakayama, Yoshitaka and Martinac, Boris (2016) Controlled delivery of drugs adsorbed onto porous Fe3O4 structures by application of AC/DC magnetic fields. Microporous and Mesoporous Materials, 226. pp. 243 - 250. ISSN ISSN:1387-1811 (PP OA)
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Abstract
Abstract Porous structures made up of Fe3O4 nanoparticles were used to adsorb methyl blue in water. Controlled release of the methyl blue to water was then achieved by application of a magnetic field. Application of a pure {DC} field did not result in any release. Application of a pure {AC} field caused released of the methyl blue. However, a combination of both {DC} and {AC} fields resulted in much faster release. The mechanism by which this operated is believed to result from viscous friction. Nanoparticles are strongly aligned in the {DC} field and oscillate under the influence of the {AC} field. This study demonstrates a concept for controlled drug delivery, where pharmaceutical molecules, similar to methyl blue, would be adsorbed onto porous Fe3O4 structure and the released at a target by application of appropriately localised magnetic fields.
| Item Type: | Article |
|---|---|
| Keywords: | Published: Elsevier May 2016 |
| Subjects: | R Medicine > R Medicine (General) |
| Depositing User: | Repository Administrator |
| Date Deposited: | 29 Apr 2016 03:28 |
| Last Modified: | 16 Jan 2018 04:22 |
| URI: | https://eprints.victorchang.edu.au/id/eprint/427 |
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