Santini, Maria Paola and Forte, Elvira and Harvey, Richard P and Kovacic, Jason C (2016) Developmental origin and lineage plasticity of endogenous cardiac stem cells. Development, 143 (8). pp.1242-58. ISSN 1477-9129 (PMC OA)
Full text not available from this repository.Abstract
Over the past two decades, several populations of cardiac stem cells have been described in the adult mammalian heart. For the most part, however, their lineage origins andin vivofunctions remain largely unexplored. This Review summarizes what is known about different populations of embryonic and adult cardiac stem cells, including KIT(+), PDGFRα(+), ISL1(+)and SCA1(+)cells, side population cells, cardiospheres and epicardial cells. We discuss their developmental origins and defining characteristics, and consider their possible contribution to heart organogenesis and regeneration. We also summarize the origin and plasticity of cardiac fibroblasts and circulating endothelial progenitor cells, and consider what role these cells have in contributing to cardiac repair.
| Item Type: | Article |
|---|---|
| Additional Information: | This article is available for free from the PMC website https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4852509/ |
| Subjects: | R Medicine > R Medicine (General) |
| Depositing User: | Repository Administrator |
| Date Deposited: | 21 Apr 2016 22:13 |
| Last Modified: | 15 Jan 2018 03:24 |
| URI: | https://eprints.victorchang.edu.au/id/eprint/418 |
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