Li, Ming and Iismaa, Siiri E and Naqvi, Nawazish and Nicks, Amy and Husain, Ahsan and Graham, Robert M (2014) Thyroid hormone action in postnatal heart development. Stem cell research, 13 (3 Pt B). pp.582-91. ISSN 1876-7753 (OA)
Full text not available from this repository.Abstract
Thyroid hormone is a critical regulator of cardiac growth and development, both in fetal life and postnatally. Here we review the role of thyroid hormone in postnatal cardiac development, given recent insights into its role in stimulating a burst of cardiomyocyte proliferation in the murine heart in preadolescence; a response required to meet the massive increase in circulatory demand predicated by an almost quadrupling of body weight during a period of about 21 days from birth to adolescence. Importantly, thyroid hormone metabolism is altered by chronic diseases, such as heart failure and ischemic heart disease, as well as in very sick children requiring surgery for congenital heart diseases, which results in low T3 syndrome that impairs cardiovascular function and is associated with a poor prognosis. Therapy with T3 or thyroid hormone analogs has been shown to improve cardiac contractility; however, the mechanism is as yet unknown. Given the postnatal cardiomyocyte mitogenic potential of T3, its ability to enhance cardiac function by promoting cardiomyocyte proliferation warrants further consideration.
| Item Type: | Article |
|---|---|
| Subjects: | R Medicine > R Medicine (General) |
| Depositing User: | Repository Administrator |
| Date Deposited: | 05 Feb 2016 05:11 |
| Last Modified: | 05 Feb 2016 05:11 |
| URI: | https://eprints.victorchang.edu.au/id/eprint/359 |
Actions (login required)
 |
View Item |