Khaw, L T and Ball, H J and Mitchell, A J and Grau, G E and Stocker, Roland and Golenser, J and Hunt, Nicholas H (2014) Brain endothelial cells increase the proliferation of Plasmodium falciparum through production of soluble factors. Experimental Parasitology, 145. pp.34-41. ISSN 1090-2449 (Not OA)
Full text not available from this repository.Abstract
We here describe the novel finding that brain endothelial cells in vitro can stimulate the growth of Plasmodium falciparum through the production of low molecular weight growth factors. By using a conditioned medium approach, we show that the brain endothelial cells continued to release these factors over time. If this mirrors the in vivo situation, these growth factors potentially would provide an advantage, in terms of enhanced growth, for sequestered parasitised red blood cells in the brain microvasculature. We observed this phenomenon with brain endothelial cells from several sources as well as a second P. falciparum strain. The characteristics of the growth factors included: <3 kDa molecular weight, heat stable, and in part chloroform soluble. Future efforts should be directed at identifying these growth factors, since blocking their production or actions might be of benefit for reducing parasite load and, hence, malaria pathology.
| Item Type: | Article |
|---|---|
| Subjects: | R Medicine > R Medicine (General) |
| Depositing User: | Repository Administrator |
| Date Deposited: | 05 Feb 2016 05:02 |
| Last Modified: | 27 Oct 2016 02:42 |
| URI: | https://eprints.victorchang.edu.au/id/eprint/356 |
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