Wang, Louis W and Jabbour, Andrew and Hayward, Christopher S and Furlong, T J and Girgis, L and Macdonald, Peter S and Keogh, Anne M (2015) Potential role of coenzyme Q10 in facilitating recovery from statin-induced rhabdomyolysis. Internal Medicine Journal, 45 (4). pp.451-3. ISSN 1445-5994 (N/A)
Full text not available from this repository.Abstract
Rhabdomyolysis is a rare, but serious complication of statin therapy, and represents the most severe end of the spectrum of statin-induced myotoxicity. We report a case where coenzyme Q10 facilitated recovery from statin-induced rhabdomyolysis and acute renal failure, which had initially persisted despite statin cessation and haemodialysis. This observation is biologically plausible due to the recognised importance of coenzyme Q10 in mitochondrial bioenergetics within myocytes, and the fact that statins inhibit farnesyl pyrophosphate production, a biochemical step crucial for coenzyme Q10 synthesis. Coenzyme Q10 is generally well tolerated, and may potentially benefit patients with statin-induced rhabdomyolysis.
| Item Type: | Article |
|---|---|
| Subjects: | R Medicine > R Medicine (General) |
| Depositing User: | Repository Administrator |
| Date Deposited: | 04 Feb 2016 03:48 |
| Last Modified: | 17 Jan 2018 08:30 |
| URI: | https://eprints.victorchang.edu.au/id/eprint/319 |
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