Rotary ATPases-dynamic molecular machines.

Stewart, Alastair G and Laming, Elise M and Sobti, Meghna and Stock, Daniela (2014) Rotary ATPases-dynamic molecular machines. Current Opinion in Structural Biology, 25. pp.40-8. ISSN 1879-033X (OA)

Abstract

Recent work has provided the detailed overall architecture and subunit composition of three subtypes of rotary ATPases. Composite models of F-type, V-type and A-type ATPases have been constructed by fitting high-resolution X-ray structures of individual components into electron microscopy derived envelopes of the intact enzymes. Electron cryo-tomography has provided new insights into the supra-molecular arrangement of eukaryotic ATP synthases within mitochondria. An inherent flexibility in rotary ATPases observed by different techniques suggests greater dynamics during operation than previously envisioned. The concerted movement of subunits within the complex might provide means of regulation and information transfer between distant parts of rotary ATPases thereby fine tuning these molecular machines to their cellular environment, while optimizing their efficiency. (NHMRC grants 1004620, 1022143, 1047004)

Metadata

Additional Information:	This is an open access article under the Creative Commons BY-NC-ND 3.0 licence (http://creativecommons.org/licenses/by-nc-nd/3.0/CC) The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. This work cannot be changed in any way or used commercially.
Subjects:	R Medicine > R Medicine (General)
Depositing User:	Repository Administrator
Date Deposited:	10 Dec 2015 23:40
Last Modified:	06 Jul 2016 05:20

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