Dao, V Thao-Vi and Casas, Ana I and Maghzal, Ghassan J and Seredenina, Tamara and Kaludercic, Nina and Robledinos-Anton, Natalia and Di Lisa, Fabio and Stocker, Roland and Ghezzi, Pietro and Jaquet, Vincent and Cuadrado, Antonio and Schmidt, Harald H H W (2015) Pharmacology and Clinical Drug Candidates in Redox Medicine. Antioxidants & Redox Signaling, 23 (14). pp.1113-29. ISSN 1557-7716 (OA)
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Abstract
SIGNIFICANCE
Oxidative stress is suggested to be a disease mechanism common to a wide range of disorders affecting human health. However, so far, the pharmacotherapeutic exploitation of this, for example, based on chemical scavenging of pro-oxidant molecules, has been unsuccessful.
RECENT ADVANCES
An alternative emerging approach is to target the enzymatic sources of disease-relevant oxidative stress. Several such enzymes and isoforms have been identified and linked to different pathologies. For some targets, the respective pharmacology is quite advanced, that is, up to late-stage clinical development or even on the market; for others, drugs are already in clinical use, although not for indications based on oxidative stress, and repurposing seems to be a viable option.
CRITICAL ISSUES
For all other targets, reliable preclinical validation and drug ability are key factors for any translation into the clinic. In this study, specific pharmacological agents with optimal pharmacokinetic profiles are still lacking. Moreover, these enzymes also serve largely unknown physiological functions and their inhibition may lead to unwanted side effects.
FUTURE DIRECTIONS
The current promising data based on new targets, drugs, and drug repurposing are mainly a result of academic efforts. With the availability of optimized compounds and coordinated efforts from academia and industry scientists, unambiguous validation and translation into proof-of-principle studies seem achievable in the very near future, possibly leading towards a new era of redox medicine. Antioxid. Redox Signal. 23, 1113-1129.
| Item Type: | Article |
|---|---|
| Additional Information: | This Open Access article is distributed under the terms of the Creative Commons CC BY-NC license http://creativecommons.org/licenses/by-nc/4.0/ |
| Subjects: | R Medicine > R Medicine (General) |
| Depositing User: | Repository Administrator |
| Date Deposited: | 02 Feb 2016 06:16 |
| Last Modified: | 28 Apr 2016 01:25 |
| URI: | https://eprints.victorchang.edu.au/id/eprint/274 |
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