Raven, Lisa M. and Greenfield, Jerry R. and Jabbour, Andrew and Macdonald, Peter S. and Muir, Christopher A. (2025) Sodium glucose cotransporter 2 inhibitors are associated with renal stabilization in heart transplantation. JHLT Open, 8. p. 100255. ISSN 29501334
Full text not available from this repository.Abstract
Sodium glucose cotransporter 2 inhibitors (SGLT2i) are standard of care for type 2 diabetes mellitus, heart failure, and chronic kidney disease (CKD). Heart transplant (HTx) recipients are at increased risk of diabetes and CKD, and both are independently associated with increased mortality. In a retrospective analysis of 104 HTx recipients with diabetes (23 exposed to SGLT2i, 81 not exposed), SGLT2i treatment was associated with stable renal function at 3 years post-HTx, measured by estimated glomerular filtration rate change from baseline (median change of 0 ml/min/1.73 m(2) (interquartile range [IQR] -13 to +11)), compared to a change of -15 ml/min/1.73 m(2) (IQR -27 to +1) in patients not exposed to SGLT2i (p = 0.02). There was no significant difference in survival by SGLT2i exposure, adjusted for diabetes type and baseline creatinine (hazard ratio 0.34, confidence intervals 0.11-1.06, p = 0.06). Further investigation of SGLT2i in HTx recipients, particularly focusing on renal outcomes, is required.
| Item Type: | Article |
|---|---|
| Subjects: | R Medicine > R Medicine (General) |
| Depositing User: | Repository Administrator |
| Date Deposited: | 05 May 2025 06:46 |
| Last Modified: | 05 May 2025 06:46 |
| URI: | https://eprints.victorchang.edu.au/id/eprint/1695 |
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