Chan, Chris H. H. and Passmore, Margaret R. and Tronstad, Oystein and Seale, Helen and Bouquet, Mahe and White, Nicole and Teruya, Jun and Hogan, Airlie and Platts, David and Chan, Wandy and Dashwood, Alexander M. and McGiffin, David C. and Maiorana, Andrew J. and Hayward, Christopher S. and Simmonds, Michael J. and Tansley, Geoff D. and Suen, Jacky Y. and Fraser, John F. and Meyns, Bart and Fresiello, Libera and Jacobs, Steven (2025) The Impact of Acute Exercise on Hemostasis and Angiogenesis Mediators in Patients With Continuous-Flow Left Ventricular Assist Devices: A Prospective Observational Pilot Study. ASAIO Journal, 71 (1). pp.11-20. ISSN 1058-2916
Full text not available from this repository.Abstract
Impaired primary hemostasis and dysregulated angiogenesis, known as a two-hit hypothesis, are associated with gastrointestinal (GI) bleeding in patients with continuous-flow left ventricular assist devices (CF-LVADs). Exercise is known to influence hemostasis and angiogenesis in healthy individuals; however, little is known about the effect in patients with CF-LVADs. The objective of this prospective observational study was to determine whether acute exercise modulates two-hit hypothesis mediators associated with GI bleeding in patients with a CF-LVAD. Twenty-two patients with CF-LVADs performed acute exercise either on a cycle ergometer for approximately 10 minutes or on a treadmill for 30 minutes. Blood samples were taken pre- and post-exercise to analyze hemostatic and angiogenic biomarkers. Acute exercise resulted in an increased platelet count ( p < 0.00001) and platelet function (induced by adenosine diphosphate, p = 0.0087; TRAP-6, p = 0.0005; ristocetin, p = 0.0009). Additionally, high-molecular-weight vWF multimers ( p < 0.00001), vWF collagen-binding activity ( p = 0.0012), factor VIII ( p = 0.034), angiopoietin-1 ( p = 0.0026), and vascular endothelial growth factor ( p = 0.0041) all increased after acute exercise. This pilot work demonstrates that acute exercise modulated two-hit hypothesis mediators associated with GI bleeding in patients with CF-LVADs.
| Item Type: | Article |
|---|---|
| Subjects: | R Medicine > R Medicine (General) |
| Depositing User: | Repository Administrator |
| Date Deposited: | 05 May 2025 00:39 |
| Last Modified: | 05 May 2025 00:39 |
| URI: | https://eprints.victorchang.edu.au/id/eprint/1653 |
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