Joshi, Yashutosh and Wang, Katherine and MacLean, Campbell and Villanueva, Jeanette and Gao, Ling and Watson, Alasdair and Iyer, Arjun and Connellan, Mark and Granger, Emily and Jansz, Paul and Macdonald, Peter (2024) The Rapidly Evolving Landscape of DCD Heart Transplantation. Current Cardiology Reports, 26 (12). pp.1499-1507. ISSN 1523-3782
Full text not available from this repository.Abstract
Abstract Purpose of Review
To summarise current international clinical outcomes from donation after circulatory death heart transplantation (DCD-HT); discuss procurement strategies, their impact on outcomes and overall organ procurement; and identify novel approaches and future areas for research in DCD-HT.
Recent Findings
Globally, DCD-HT survival outcomes (regardless of procurement strategy) are comparable to heart transplantation from brain dead donors (BDD). Experience with normothermic machine perfusion sees improvement in rates of primary graft dysfunction. Techniques have evolved to reduce cold ischaemic exposure to directly procured DCD hearts, though controlled periods of cold ischaemia can likely be tolerated. There is interest in hypothermic machine perfusion (HMP) for directly procured DCD hearts, with promising early results.
Summary
Survival outcomes are firmly established to be equivalent between BDD and DCD-HT. Procurement strategy (direct procurement vs. regional perfusion) remains a source of debate. Methods to improve allograft warm ischaemic tolerance are of interest and will be key to the uptake of HMP for directly procured DCD hearts.
| Item Type: | Article |
|---|---|
| Subjects: | R Medicine > R Medicine (General) |
| Depositing User: | Repository Administrator |
| Date Deposited: | 05 May 2025 00:21 |
| Last Modified: | 05 May 2025 00:21 |
| URI: | https://eprints.victorchang.edu.au/id/eprint/1647 |
Actions (login required)
 |
View Item |