D’Ambrosio, Paolo and Claessen, Guido and Kistler, Peter M and Heidbuchel, Hein and Kalman, Jonathan M and La Gerche, André (2024) Ventricular arrhythmias in association with athletic cardiac remodelling. Europace, 26 (12). ISSN 1099-5129
Full text not available from this repository.Abstract
Abstract
Athletes are predisposed to atrial arrhythmias but the association between intense endurance exercise training, ventricular arrhythmias (VAs), and sudden cardiac death is less well established. Thus, it is unclear whether the ‘athlete’s heart’ promotes specific arrhythmias or whether it represents a more general pro-arrhythmogenic phenotype. Whilst direct causality has not been established, it appears possible that repeated exposure to high-intensity endurance exercise in some athletes contributes to formation of pro-arrhythmic cardiac phenotypes that underlie VAs. Theories regarding potential mechanisms for exercise-induced VAs include repeated bouts of myocardial inflammation and stretch-induced cellular remodelling. Small animal models provide some insights, but larger animal and human data are sparse.
The current clinical approach to VAs in athletes is to differentiate those with and without structural or electrical heart disease. However, if the athlete’s heart involves a degree of pro-arrhythmogenic remodelling, then this may not be such a simple dichotomy. Questions are posed by athletes with VAs in combination with extreme remodelling. Some markers, such as scar on magnetic resonance imaging, may point towards a less benign phenotype but are also quite common in ostensibly healthy athletes. Other clinical and invasive electrophysiology features may be helpful in identifying the at-risk athlete.
This review seeks to discuss the association between athletic training and VAs. We will discuss the potential mechanisms, clinical significance, and approach to the management of athletes with VAs.
| Item Type: | Article |
|---|---|
| Subjects: | R Medicine > R Medicine (General) |
| Depositing User: | Repository Administrator |
| Date Deposited: | 02 May 2025 04:40 |
| Last Modified: | 02 May 2025 04:40 |
| URI: | https://eprints.victorchang.edu.au/id/eprint/1632 |
Actions (login required)
 |
View Item |