Chen, Sing-Young and Beretta, Martina and Olzomer, Ellen M. and Alexopoulos, Stephanie J. and Shah, Divya P. and Byrne, Frances L. and Salamoun, Joseph M. and Garcia, Christopher J. and Smith, Greg C. and Larance, Mark and Philp, Andrew and Turner, Nigel and Santos, Webster L. and Cantley, James and Hoehn, Kyle L. (2024) Head-to-head comparison of BAM15, semaglutide, rosiglitazone, NEN, and calorie restriction on metabolic physiology in female db/db mice. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 1870 (1). p. 166908. ISSN 09254439
Full text not available from this repository.Abstract
Metabolic disorders such as type 2 diabetes, fatty liver disease, hyperlipidemia, and obesity commonly co-occur but clinical treatment options do not effectively target all disorders. Calorie restriction, semaglutide, rosiglitazone, and mitochondrial uncouplers have all demonstrated efficacy against one or more obesity-related metabolic disorders, but it currently remains unclear which therapeutic strategy best targets the combination of hyperglycaemia, liver fat, hypertriglyceridemia, and adiposity. Herein we performed a head-to-head comparison of 5 treatment interventions in the female db/db mouse model of severe metabolic disease. Treatments included approximately 60 % calorie restriction (CR), semaglutide, rosiglitazone, BAM15, and niclosamide ethanolamine (NEN). Results showed that BAM15 and CR improved body weight and liver steatosis to levels superior to semaglutide, NEN, and rosiglitazone, while BAM15, semaglutide, and rosiglitazone improved glucose tolerance better than CR and NEN. BAM15, CR, semaglutide, and rosiglitazone all had efficacy against hypertriglyceridaemia. These data provide a comprehensive head-to-head comparison of several key treatment strategies for metabolic disease and highlight the efficacy of mitochondrial uncoupling to correct multiple facets of the metabolic disease milieu in female db/db mice.
| Item Type: | Article |
|---|---|
| Subjects: | R Medicine > R Medicine (General) |
| Depositing User: | Repository Administrator |
| Date Deposited: | 13 Dec 2024 04:59 |
| Last Modified: | 13 Dec 2024 04:59 |
| URI: | https://eprints.victorchang.edu.au/id/eprint/1501 |
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