Molecular biomarkers for vascular cognitive impairment and dementia

Hosoki, Satoshi and Hansra, Gurpreet K. and Jayasena, Tharusha and Poljak, Anne and Mather, Karen A. and Catts, Vibeke S. and Rust, Ruslan and Sagare, Abhay and Kovacic, Jason C. and Brodtmann, Amy and Wallin, Anders and Zlokovic, Berislav V. and Ihara, Masafumi and Sachdev, Perminder S. (2023) Molecular biomarkers for vascular cognitive impairment and dementia. Nature Reviews Neurology, 19 (12). pp.737-753. ISSN 1759-4758

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As disease-specific interventions for dementia are being developed, the ability to identify the underlying pathology and dementia subtypes is increasingly important. Vascular cognitive impairment and dementia (VCID) is the second most common cause of dementia after Alzheimer disease, but progress in identifying molecular biomarkers for accurate diagnosis of VCID has been relatively limited. In this Review, we examine the roles of large and small vessel disease in VCID, considering the underlying pathophysiological processes that lead to vascular brain injury, including atherosclerosis, arteriolosclerosis, ischaemic injury, haemorrhage, hypoperfusion, endothelial dysfunction, blood-brain barrier breakdown, inflammation, oxidative stress, hypoxia, and neuronal and glial degeneration. We consider the key molecules in these processes, including proteins and peptides, metabolites, lipids and circulating RNA, and consider their potential as molecular biomarkers alone and in combination. We also discuss the challenges in translating the promise of these biomarkers into clinical application.

Item Type: Article
Subjects: R Medicine > R Medicine (General)
Depositing User: Repository Administrator
Date Deposited: 02 May 2024 06:27
Last Modified: 02 May 2024 06:27

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