Generation of induced pluripotent stem cell lines from a sister pair who suffered post-partum or recurrent Spontaneous Coronary Artery Dissections

Bax, Monique and Junday, Keerat and Iismaa, Siiri E and Kaidonis, Xenia and Muller, David and Hesselson, Stephanie and Graham, Robert M (2023) Generation of induced pluripotent stem cell lines from a sister pair who suffered post-partum or recurrent Spontaneous Coronary Artery Dissections. Stem Cell Research, 73. p. 103238. ISSN 18735061

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Link to published document: http://doi.org/10.1016/j.scr.2023.103238

Abstract

Spontaneous Coronary Artery Dissection (SCAD) results from a bleed within a coronary artery wall that impairs blood flow as it expands. It is the most common cause of myocardial infarction in pregnant women. Here, peripheral blood mononuclear cells from two sisters who had suffered SCADs were reprogrammed using Sendai Virus. Expression of pluripotency markers, capability to differentiate to the three germ layers, and cellular integrity were confirmed. This is the first report of a SCAD family induced pluripotent stem cell (iPSC) cohort, including a sister who suffered post-partum SCAD, and one who suffered from multiple recurrences.

Item Type: Article
Subjects: R Medicine > R Medicine (General)
Depositing User: Repository Administrator
Date Deposited: 02 May 2024 04:27
Last Modified: 02 May 2024 04:27
URI: http://eprints.victorchang.edu.au/id/eprint/1482

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