A mitochondrial cytopathy presenting with persistent troponin elevation: case report

Krishnan, Anish and Wu, Kathy and Girgis, Laila and Pamphlett, Roger and Tomlinson, Susan and Muthiah, Kavitha and Safarova, Maya S and Anagnostopoulou, Andriana and Cosmi, Deborah and Khosla, Jagjit and Monosilio, Sara and Abdullah, Abdyullah (2023) A mitochondrial cytopathy presenting with persistent troponin elevation: case report. European Heart Journal - Case Reports, 7 (4). ISSN 2514-2119

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Link to published document: http://doi.org/10.1093/ehjcr/ytad132


BACKGROUND: Mitochondrial diseases represent an important potential cause of cardiomyopathy and should be considered in patients presenting with multisystem manifestations. Timely diagnosis of a mitochondrial disorder is needed as it can have reproductive implications for the offspring of the proband. CASE SUMMARY: We describe a case of undifferentiated rising and persistent troponin elevation in a 70-year-old female with only mild heart failure symptoms and signs. An eventual diagnosis of a mitochondrial cytopathy was made after genetic testing, striated muscle, and endomyocardial biopsy. Multidisciplinary involvement was vital in securing the ultimate diagnosis and is a key lesson from this case. On follow up, with institution of heart failure therapy including cardiac resynchronisation device therapy there was improvement in exercise tolerance and symptoms. DISCUSSION: For discussion is the investigation of undifferentiated cardiomyopathies and consideration of mitochondrial disorders as an important diagnosis to exclude prior to diagnosis as an idiopathic cardiomyopathy.

Item Type: Article
Subjects: R Medicine > R Medicine (General)
Depositing User: Repository Administrator
Date Deposited: 10 Jul 2023 03:46
Last Modified: 10 Jul 2023 04:55
URI: http://eprints.victorchang.edu.au/id/eprint/1410

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